Hydrogen decreases susceptibility to AngII-induced atrial fibrillation and atrial fibrosis via the NOX4/ROS/NLRP3 and TGF-β1/Smad2/3 signaling pathways.

Atrial fibrillation (AF) represents the commonly occurring cardiac arrhythmia and the main factor leading to stroke and heart failure. Hydrogen (H2) is a gaseous signaling molecule that has the effects of anti-inflammation and antioxidation. Our study provides evidence that hydrogen decreases susceptibility to AngII-mediated AF together with atrial fibrosis.

Impact of DNAH3 Deficiency on Sperm Energy Metabolism and Motility Leading to Asthenozoospermia.

Asthenozoospermia, a prevalent contributor to male infertility, exhibits a multifaceted pathogenesis. This study identified a significant downregulation in sperm dynein heavy chain 3 (DNAH3) protein levels in individuals with asthenozoospermia. To elucidate the role of DNAH3 in asthenozoospermia, we constructed Dnah3-knockout (KO) mice, which exhibited asthenozoospermia and sterility.

Transgenerational associations between newborn metabolic profiles and bronchopulmonary dysplasia in neonates born to mothers with an obese phenotype.

Maternal obesity increases risk for bronchopulmonary dysplasia (BPD) by up to 42%. Identifying metabolic features that may contribute to the association between maternal pre-pregnancy body mass index (BMI) and BPD is critical in defining the molecular relationship between these conditions. We investigated the association between maternal obesity and BPD using newborn screen metabolites as an explanatory variable.

A metric and its derived protein network for evaluation of ortholog database inconsistency.

Background: Ortholog prediction, essential for various genomic research areas, faces growing inconsistencies amidst the expanding array of ortholog databases. The common strategy of computing consensus orthologs introduces additional arbitrariness, emphasizing the need to examine the causes of such inconsistencies and identify proteins susceptible to prediction errors.

Results: We introduce the Signal Jaccard Index (SJI), a novel metric rooted in unsupervised genome context clustering, designed to assess protein similarity.

Effect of different restorative design and materials on stress distribution in cracked teeth: a finite element analysis study.

Objectives: To compare the stress distribution and crack propagation in cracked mandibular first molar restored with onlay, overlay, and two types of occlusal veneers using two different CAD/CAM materials by Finite Element Analysis (FEA).

Materials And Methods: A mandibular first molar was digitized using a micro CT scanning system in 2023. Three-dimensional dynamic scan data were transformed, and a 3D model of a cracked tooth was generated.

Single-Atom Suture.

In atomically thin two-dimensional (2D) materials, grain boundaries (GBs) are ubiquitous, displaying a profound effect on the electronic structure of the host lattice. The random configuration of atoms within GBs introduces an arbitrary and unpredictable local electronic environment, which may hazard electron transport. Herein, by utilizing the Pt single-atom chains with an ultimate one-dimensional (1D) feature (width of a single atom and length up to tens of nanometers), we realized the suture of the electron pathway at GBs of diversified transition metal dichalcogenides (TMDCs).

A 35 nV/√Hz Analog Front-End Circuit with Adjustable Bandwidth and Gain in UMC 40 nm CMOS for Biopotential Signal Acquisition.

This paper presents a 35 nV/√Hz analog front-end (AFE) circuitdesigned in the UMC 40 nm CMOS technology for the acquisition of biopotential signal. The proposed AFE consists of a capacitive-coupled instrumentation amplifier (CCIA) and a combination of a programmable gain amplifier (PGA) and a low-pass filter (LPF). The CCIA includes a DC servo loop (DSL) to eliminate electrode DC offset (EDO) and a ripple rejection loop (RRL) with self-zeroing technology to suppress high-frequency ripples caused by the chopper.

Integrative Analysis of Pharmacology and Transcriptomics Predicts Resveratrol Will Ameliorate Microplastics-Induced Lung Damage by Targeting Ccl2 and Esr1.

Background: Microplastics (MPs) are ubiquitous on earth, posing a growing threat to human health. Previous studies have shown that the lung is a primary organ for MPs exposure. Resveratrol (RES) is a common dietary polyphenol that exhibits anti-inflammatory and antioxidant effects.

Characterization and Transcriptional Regulation of the 2-Ketogluconate Utilization Operon in .

JUIM01 is an industrial 2-keto-d-gluconate (2KGA)-producing strain. However, its regulation mechanism of 2KGA metabolism remains to be clarified. Among other reported species, the 2-ketogluconate utilization operon ( operon) plays key roles in 2KGA catabolism.

Environmental Changes Driving Shifts in the Structure and Functional Properties of the Symbiotic Microbiota of .

Symbiotic microbiota significantly influence the development, physiology, and behavior of their hosts, and therefore, they are widely studied. However, very few studies have investigated the changes in symbiotic microbiota across generations. originating from the Qinghai-Tibetan Plateau were cultured through seven generations in our laboratory, and the symbiotic microbiota of were sequenced using a 16S rRNA amplicon to analyze changes in the structure and functional properties of the symbiotic microbiota of from a harsh environment to an ideal environment.

One-Step Multiplex Real-Time Fluorescent Quantitative Reverse Transcription PCR for Simultaneous Detection of Four Waterfowl Viruses.

Duck Tembusu virus (DTMUV), duck hepatitis virus (DHV), Muscovy duck reovirus (MDRV), and Muscovy duck parvovirus (MDPV) represent four emergent infectious diseases impacting waterfowl, which can be challenging to differentiate due to overlapping clinical signs. In response to this, we have developed a one-step multiplex real-time fluorescence quantitative reverse transcription PCR (qRT-PCR) assay, capable of simultaneously detecting DTMUV, DHV, MDRV, and MDPV. This method exhibits high specificity, avoiding cross-reactivity with other viruses such as Fowl adenoviruses (FADV), infectious bursal disease virus (IBDV), infectious bronchitis virus (IBV), infectious laryngotracheitis virus (ILTV), Haemophilus paragallinarum (Hpg), duck circovirus (DUCV), goose astrovirus (GoAstV), and mycoplasma gallisepticum (MG).

Effects of Semaglutide and Tirzepatide on Bone Metabolism in Type 2 Diabetic Mice.

Type 2 diabetes and weight loss are associated with detrimental skeletal health. Incretin-based therapies (GLP-1 receptor agonists, and dual GIP/GLP-1 receptor agonists) are used clinically to treat diabetes and obesity. The potential effects of semaglutide and tirzepatide on bone metabolism in type 2 diabetic mice remain uncertain.

Polyphenol Profile and Antioxidant, Antityrosinase, and Anti-Melanogenesis Activities of Ethanol Extract of Bee Pollen.

Bee pollen, a rich nutritional food, was employed to develop a raw material for skin whitening. The polyphenol profile and antioxidant, antityrosinase, and anti-melanogenesis activities of the ethanol extracts of five species of bee pollens (EEBPs) were determined. The results showed that there were a total of 121 phenolic compounds in these EEBPs.

Sintering Ag Nanoclusters on TiO Nanoparticles as an Efficient Catalyst for Nitroarene Reduction.

Polydispersed Ag species-modified TiO samples with abundant oxygen vacancies were successfully prepared through the calcination of atomically precise Ag nanocluster-loaded TiO at an optimal temperature under a nitrogen atmosphere. The ligands of the Ag nanoclusters are removed by extracting lattice oxygen from TiO during the calcination, leading to the formation of CO, SO, and HO vapor. This process simultaneously induces Ag species sintering on the surface of TiO.

Advances in Research on Southern Corn Rust, a Devasting Fungal Disease.

Southern corn rust (SCR), caused by the obligate biotrophic fungus Underw., represents one of the most devastating threats to maize production, potentially resulting in yield losses exceeding 50%. Due to global climate change and cropping practices, epiphytotics of SCR have been increasingly reported, and are progressively spreading from tropical and subtropical maize growing areas to higher latitude areas.

Compared Inhibitory Activities of Tamoxifen and Avenanthramide B on Liver Esterase and Correlation Based on the Superimposed Structure Between Porcine and Human Liver Esterase.

Exposure to tamoxifen can exert effects on the human liver, and esterases process prodrugs such as antibiotics and convert them to less toxic metabolites. In this study, the porcine liver esterase (PLE)-inhibitory activity of tamoxifen has been investigated. PLE showed inhibition of a PLE isoenzyme (PLE5).

Long-Term Outcomes of Modified Expansive Open-Door Laminoplasty Combined with Short-Level Anterior Cervical Fusion in Multilevel Cervical Spondylotic Myelopathy.

: Multilevel cervical spondylotic myelopathy (MCSM) presents complex challenges for surgical management, particularly in patients with kyphosis or significant anterior pathology. This study aimed to assess the long-term efficacy of modified expansive open-door laminoplasty (MEOLP) combined with short-level anterior cervical fusion (ACF) in providing decompression, preserving alignment, and maintaining range of motion (ROM) over a nine-year follow-up. : A retrospective analysis was conducted on 124 MCSM patients treated with MEOLP combined with ACF between 2011 and 2015.

Crosstalk Within the Intestinal Epithelium: Aspects of Intestinal Absorption, Homeostasis, and Immunity.

Gut health is crucial in many ways, such as in improving human health in general and enhancing production in agricultural animals. To maximize the effect of a healthy gastrointestinal tract (GIT), an understanding of the regulation of intestinal functions is needed. Proper intestinal functions depend on the activity, composition, and behavior of intestinal epithelial cells (IECs).

Ripening Study Based on Multi-Structural Inversion of Cherry Tomato qMRI.

This study introduces a non-destructive, quantitative method using low-field MRI to assess moisture mobility and content distribution in cherry tomatoes. This study developed an advanced 3D non-local mean denoising model to enhance tissue feature analysis and applied an optimized TransUNet model for structural segmentation, obtaining multi-echo data from six tissue types. The structural T2 relaxation inversion was refined by integrating an ACS-CIPSO algorithm.

Identification of Candidate Genes for Sebum Deposition in Pekin Ducks Using Genome-Wide Association Studies.

Background: Sebum deposition is a vital trait influencing meat quality and production efficiency in Pekin ducks. Providing insights into the genetic basis of fat deposition could help improve breeding strategies aimed at producing high-quality meat ducks. This study aimed to identify the genetic mechanisms and lipid metabolism pathways regulating subcutaneous and intramuscular fat deposition in two Pekin duck strains: Nankou No.

Identification and Bioactivity Analysis of a Novel Species, sp. nov. Bos-x6-28, Isolated from Feces of the Yak ().

The identification of novel bacterial species from the intestines of yaks residing on the Qinghai-Tibet Plateau is pivotal in advancing our understanding of host-microbiome interactions and represents a promising avenue for microbial drug discovery. In this study, we conducted a polyphasic taxonomic analysis and bioactive assays on a strain, designated Bos-x6-28, isolated from yak feces. The findings revealed that strain Bos-x6-28 shares a high 16S rRNA gene sequence similarity (98.

Correction of Multispectral Singlet Oxygen Luminescent Dosimetry (MSOLD) for Tissue Optical Properties in Photofrin-Mediated Photodynamic Therapy.

The direct detection of singlet-state oxygen (O) constitutes the holy grail dosimetric method for type-II photodynamic therapy (PDT), a goal that can be quantified using multispectral singlet oxygen near-infrared luminescence dosimetry (MSOLD). The optical properties of tissues, specifically their scattering and absorption coefficients, play a crucial role in determining how the treatment and luminescence light are attenuated. Variations in these properties can significantly impact the spatial distribution of the treatment light and hence the generation of singlet oxygen and the detection of singlet oxygen luminescence signals.

[Mitoxantrone hydrochloride liposome combined with cytarabine for treating pediatric acute myeloid leukemia with RUNX1∷MTG16 fusion gene: a case report and literature review].

This case report presents a patient with pediatric acute myeloid leukemia (AML) with RUNX1∷MTG16, admitted to the Blood Disease Hospital of the Chinese Academy of Medical Sciences in October 2023. He was 13 years old, with a chief complaint of fatigue for 20 days. Bone marrow smear revealed 17.

Electrolyte Chemistry Towards Ultra-High Voltage (4.7 V) And Ultra-Wide Temperature (-30 to 70 °C) LiCoO Batteries.

LiCoO batteries for 3 C electronics demand high charging voltage and wide operating temperature range, which are virtually impossible for existing electrolytes due to aggravated interfacial parasitic reactions and sluggish kinetics. Herein, we report an electrolyte design strategy based on a partially fluorinated ester solvent (i.e.