On the Mechanism of the Reaction of alpha-Substituted Ketones with Allyltributylstannane.

The mechanisms for the reaction of allyltributylstannane with a number of fragmentation probes, alpha-substituted acetophenones, were studied. All reactions were shown to proceed through free radical chain sequences since they could be initiated by AIBN and inhibited by m-dinitrobenzene (DNB). alpha-Halo- and alpha-(benzoyloxy)acetophenones (I and II, PhCOCR(1)R(2)X; X = F, Cl, Br, OCOPh; R(1), R(2) = H, Me) yielded the allylation products, PhCOCR(1)R(2)CH(2)CH=CH(2)), through a chain sequence involving as the propagation step: an electron transfer from Bu(3)Sn(*) to I and II, fragmentation of the ketyl anion PhCOCR(1)R(2)X(*)(-), and addition of PhCOCR(1)R(2)(*) to allyltributylstannane.

A chromosome study on 97 cases of acute nonlymphocytic leukemia M2.

Chromosomal studies were performed in the same laboratory on 97 untreated cases of de novo acute nonlymphocytic leukemia M2. The overall incidence of chromosomal abnormality was 70.1% (68 out of 97 cases), which was higher in children (84.

Interaction of Mycoplasma pneumoniae with HeLa cells.

The susceptibility of HeLa cells to Mycoplasma pneumoniae-induced injury was examined. Infections were initiated with relatively low mycoplasma doses, carried out in a culture medium incapable of supporting M. pneumoniae replication in the absence of host cells, and monitored for up to 10 days.