Publications by authors named "Y-L Jiang"

Background: We investigated the corneal biomechanical properties and their genotype-phenotype correlation correlations in patients with Marfan syndrome (MFS) and ectopia lentis (EL).

Methods: Patients with MFS with EL underwent panel-based next-generation sequencing in this retrospective cohort study. The FBN1 genotypes were categorized into the dominant-negative (DN) group and the haploinsufficiency (HI) group.

View Article and Find Full Text PDF

Genomic profiling of central nervous system (CNS) metastases has the potential to guide treatments. In the present study, we included 584 patients with non-small-cell lung cancer and CNS metastases and performed a comprehensive analysis of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) with clinicopathological annotation. CSF ctDNA-positive detection was independently associated with shorter survival than negative detection (hazard ratio (HR) = 1.

View Article and Find Full Text PDF

Three-dimensional structured illumination microscopy (3DSIM) is a popular method for observing subcellular/cellular structures or animal/plant tissues with gentle phototoxicity and 3D super-resolution. However, its time-consuming reconstruction process poses challenges for high-throughput imaging and real-time observation. Moreover, traditional 3DSIM typically requires more than six layers for successful reconstruction and is susceptible to defocused backgrounds.

View Article and Find Full Text PDF

Quality control (QC) in mass spectrometry (MS)-based proteomics is mainly based on data-dependent acquisition (DDA) analysis of standard samples. Here, we collect 2754 files acquired by data independent acquisition (DIA) and paired 2638 DDA files from mouse liver digests using 21 mass spectrometers across nine laboratories over 31 months. Our data demonstrate that DIA-based LC-MS/MS-related consensus QC metrics exhibit higher sensitivity compared to DDA-based QC metrics in detecting changes in LC-MS status.

View Article and Find Full Text PDF

The use of single-cell combinatorial indexing sequencing via droplet microfluidics presents an attractive approach for balancing cost, scalability, robustness and accessibility. However, existing methods often require tailored protocols for individual modalities, limiting their automation potential and clinical applicability. To address this, we introduce UDA-seq, a universal workflow that integrates a post-indexing step to enhance throughput and systematically adapt existing droplet-based single-cell multimodal methods.

View Article and Find Full Text PDF

Rationale And Objectives: Cognitive disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD), significantly impact the quality of life in older adults. Mild cognitive impairment (MCI) is a critical stage for intervention and can predict the development of dementia. The causes of these two diseases are not fully understood, but there is an overlap in their neuropathology.

View Article and Find Full Text PDF

Modular polyketide synthases (mPKSs) are multidomain enzymes in bacteria that synthesize a variety of pharmaceutically important compounds. mPKS genes are usually longer than 10 kb and organized in operons. To understand the transcriptional and translational characteristics of these large genes, here we split the 13-kb busA gene, encoding a 456-kDa three-module PKS for butenyl-spinosyn biosynthesis, into three smaller separately translated genes encoding one PKS module in an operon.

View Article and Find Full Text PDF

Background: Metabolic syndrome heightens cardiovascular disease risk primarily through increased arterial stiffness. We previously demonstrated the involvement of YAP (Yes-associated protein) in high-fat/high-sucrose diet (HFHSD)-induced arterial stiffness via modulation of PPM1B (protein phosphatase Mg/Mn-dependent 1B)-lysine 63(K63) deubiquitination. In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness.

View Article and Find Full Text PDF

More than 2 000 yeast strains isolated from 1 200 samples mostly collected from Tibet and Yunnan provinces in China were identified as 462 species according to the internal transcribed spacer including the 5.8S rDNA (ITS) and the D1/D2 domains of the large subunit rDNA (LSU) sequence analyses. Among them, 70 new basidiomycetous yeast species were proposed based on the multi-locus phylogenetic analyses including the D1/D2 domains, the ITS, the small subunit rDNA (SSU), the largest subunit of RNA polymerase II (), the second largest subunit of RNA polymerase II () and translation elongation factor 1-α (), as well as the phenotypic comparisons.

View Article and Find Full Text PDF

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.

View Article and Find Full Text PDF

Background: Currently, validated biomarkers for assessing hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) are lacking. We aimed to validate a test combining GFAP (glial fibrillary acidic protein) and UCH-L1 (ubiquitin C-terminal hydrolase-L1) to indicate the absence of HT after IVT.

Methods: We prospectively enrolled consecutive patients with stroke treated with IVT from 16 hospitals.

View Article and Find Full Text PDF

Background: Physical literacy (PL) can positively affect the health of children, adolescents, and adults, and is closely related to cardiorespiratory fitness (CRF).

Objective: To perform a systematic review and meta-analysis to examine the relationship between overall physical literacy (PL) and CRF in children and adolescents.

Methods: Cross-sectional, cohort and experimental studies on the relationship between PL and CRF in children and adolescents were collected by searching the Web of Science Core Collection, PubMed, EBSCOhost, ScienceDirect, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases.

View Article and Find Full Text PDF

Background: Colonoscopy remains the predominant diagnostic modality for colorectal cancer (CRC), as the diagnostic performance of tumor markers in alone, particularly in the early stages of the disease, is limited. This study sought to develop a diagnostic model for CRC that integrated various laboratory parameters.

Methods: One hundred patients with CRC were assigned to an experimental group while 114 with benign colorectal diseases and 101 healthy individuals were assigned to a control group.

View Article and Find Full Text PDF

Background: Dual-energy computed tomography (DECT) has demonstrated the feasibility of using HAP-water to respond to BMD changes without requiring dedicated software or calibration. Artificial intelligence (AI) has been utilized for diagnosising osteoporosis in routine CT scans but has rarely been used in DECT. This study investigated the diagnostic performance of an AI system for osteoporosis screening using DECT images with reference quantitative CT (QCT).

View Article and Find Full Text PDF

Background: Gallbladder cancer (GBC) was once considered a contraindication for laparoscopic surgery, but it is becoming more common to use laparoscopic surgery for GBC treatment. The aim of this study was to analyze the long- and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network (NCCN) after laparoscopic resection (LR) versus open resection (OR).

Methods: A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2016 and 2020.

View Article and Find Full Text PDF

Rationale And Objectives: Accurate prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is crucial for guiding treatment. This study evaluates and compares the performance of clinicoradiologic, traditional radiomics, deep-learning radiomics, feature fusion, and decision fusion models based on multi-region MR habitat imaging using six machine-learning classifiers.

Materials And Methods: We retrospectively included 300 HCC patients.

View Article and Find Full Text PDF

Micro-stereolithography (μSL) is an advanced additive manufacturing technique that enables the fabrication of highly precise microstructures with fine feature resolution. One of the primary challenges in μSL is achieving and maintaining precise focus throughout the fabrication process. For the successful application of μSL, it is essential to maintain the sample surface within a focal depth of several microns.

View Article and Find Full Text PDF

Background: Deucravacitinib, an oral selective allosteric tyrosine kinase 2 inhibitor, is approved in the USA, the European Union, Japan, South Korea, China and other countries for the treatment of moderate-to-severe plaque psoriasis.

Objectives: To evaluate the efficacy and safety of deucravacitinib in Asian patients with moderate-to-severe plaque psoriasis.

Methods: In the 52-week blinded phase III POETYK PSO-3 trial (NCT04167462), patients were randomized 1 : 2 to placebo (n = 74) or deucravacitinib 6 mg once daily (n = 146) for 16 weeks followed by deucravacitinib alone.

View Article and Find Full Text PDF
Article Synopsis
  • * The researchers developed high-performance fluorescent biosensors called sensitive to arginine (STAR) that allow for real-time monitoring of arginine levels in cells, mice, and clinical samples.
  • * Using STAR, they discovered the influence of different amino acids on arginine levels and found that serum arginine levels tend to rise with age, which could help in assessing the progression of conditions like vitiligo.
View Article and Find Full Text PDF
Article Synopsis
  • The study aims to improve prediction of 90-day functional outcomes in ischemic stroke patients using a deep learning model that combines non-contrast CT images and clinical data, potentially aiding healthcare planning and clinical trials.
  • The dataset included 1,335 patients from multiple trials and registries, and the model demonstrated superior accuracy in predicting outcomes compared to models using only imaging or clinical data alone.
  • The fused model achieved a mean absolute error (MAE) of 0.94 for mRS score prediction and an AUC of 0.91 for identifying unfavorable outcomes, indicating it significantly outperforms existing methods.
View Article and Find Full Text PDF
Article Synopsis
  • A multicenter randomized controlled trial in China investigated the impact of adding coronary CT-derived fractional flow reserve (CT-FFR) to routine coronary CT angiography (CCTA) on the need for invasive coronary angiography (ICA) and major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).
  • The study involved 5,297 participants, showing that the CCTA plus CT-FFR group had a lower ICA rate (10.0%) compared to the CCTA alone group (12.4%) over a 90-day follow-up.
  • While MACE rates were similar between groups, the CCTA plus CT-FFR approach resulted in fewer cardiac events after one year (0.5%
View Article and Find Full Text PDF

Background: Atherosclerosis is the most common cause of cardiovascular diseases. Clinical studies indicate that loss-of-function ASGR1 (asialoglycoprotein receptor 1) is significantly associated with lower plasma cholesterol levels and reduces cardiovascular disease risk. However, the effect of ASGR1 on atherosclerosis remains incompletely understood; whether inhibition of ASGR1 causes liver injury remains controversial.

View Article and Find Full Text PDF
Article Synopsis
  • Scientists created a computer program called ReportGuidedNet that helps find brain problems in MRI scans by using information from radiology reports.
  • They tested this program on thousands of brain scans from different hospitals and compared it to another program called PlainNet that didn’t use report info.
  • ReportGuidedNet did a much better job at diagnosing brain conditions and understanding where to look on the scans, making it more reliable and easier to explain its findings.
View Article and Find Full Text PDF
Article Synopsis
  • This study aimed to evaluate long-term changes in Life's Essential 8 (LE8) components and their relationship with stroke risk in a large group of Chinese participants over a decade.
  • Researchers tracked 26,719 individuals without prior stroke history, identifying five different trajectory patterns of LE8 from 2006 to 2016 and documenting nearly 500 stroke cases by 2020.
  • Results showed that higher and more stable LE8 scores significantly reduced stroke risk, indicating that improved cardiovascular health can lessen stroke likelihood, even if starting levels were low.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessioni0st2o96l5rafl8pf4l9h65intcaju14): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once