Publications by authors named "Y-L Hu"
Historically, the standard of care for advanced biliary tract cancers (aBTCs) was gemcitabine plus cisplatin (GemCis). Immunotherapy plus GemCis is now recommended as a first-line treatment for aBTCs. Whether patients can tolerate eight cycles of GemCis in clinical practice, as per the Advanced Biliary Cancer (ABC)-02 study, remains to be assessed.
View Article and Find Full Text PDFMore than 2 000 yeast strains isolated from 1 200 samples mostly collected from Tibet and Yunnan provinces in China were identified as 462 species according to the internal transcribed spacer including the 5.8S rDNA (ITS) and the D1/D2 domains of the large subunit rDNA (LSU) sequence analyses. Among them, 70 new basidiomycetous yeast species were proposed based on the multi-locus phylogenetic analyses including the D1/D2 domains, the ITS, the small subunit rDNA (SSU), the largest subunit of RNA polymerase II (), the second largest subunit of RNA polymerase II () and translation elongation factor 1-α (), as well as the phenotypic comparisons.
View Article and Find Full Text PDFReduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to evaluate the effectiveness and quality of radiomics models in diagnosing osteoporosis through a comprehensive meta-analysis.
- Significant findings from 25 studies revealed that these models have high diagnostic accuracy, with a pooled sensitivity and specificity of 0.90, and an area under the curve (AUC) of 0.96.
- The research indicates that variations in imaging methods might affect diagnostic performance, but models using CT and deep learning show particularly high efficacy.
Rationale And Objectives: Patients with a low Agatston score often present with clinical signs and symptoms suggestive of coronary artery disease, despite having minimal calcium deposits. This study aimed to compare the efficacy of low-dose non-contrast cardiac CT with coronary computed tomography angiography (CCTA) in pericoronary adipose tissue (PCAT) radiomics for predicting coronary artery plaques, using CCTA as the reference standard.
Materials And Methods: This retrospective study analyzed 459 patients with suspected coronary artery disease and a coronary artery calcium score < 100 Agatston units, who were treated between June 2021 and December 2023 at a tertiary hospital.
Background: Pulmonary hypertension (PH) is associated with endothelial dysfunction. However, the cause of endothelial dysfunction and its impact on PH remain incompletely understood. We aimed to investigate whether the hypoxia-inducible FUNDC1 (FUN14 domain-containing 1)-dependent mitophagy pathway underlies PH pathogenesis and progression.
View Article and Find Full Text PDFSerum GFAP and UCH-L1 Levels for the Assessment of the Absence of Hemorrhagic Transformation: A Multicenter Prospective Cohort Study.
Stroke
January 2025
Background: Currently, validated biomarkers for assessing hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) are lacking. We aimed to validate a test combining GFAP (glial fibrillary acidic protein) and UCH-L1 (ubiquitin C-terminal hydrolase-L1) to indicate the absence of HT after IVT.
Methods: We prospectively enrolled consecutive patients with stroke treated with IVT from 16 hospitals.
Article Synopsis
- Prostate cancer (PC) is becoming more common in Asian countries, but there is limited data on its treatment and outcomes in this population.
- The United in Fight against prOstate cancer (UFO) registry was established to observe and document the characteristics and treatment experiences of PC patients across eight Asian regions from 2015 to 2020.
- Findings from the registry revealed varying patient demographics, with many presenting with advanced disease and poor quality-of-life scores, suggesting a significant need for better access to modern treatments in Asia to enhance patient outcomes.
Rationale And Objectives: The escalating incidence of placental accreta spectrum (PAS), a pregnancy complication, underscores the need for accurate prenatal diagnosis to guide optimal management strategies. This study aims to develop, validate, and compare various prenatal PAS prediction models integrating clinical data, MRI signs, and radiomics signatures.
Materials And Methods: A cohort comprising 111 patients (72 with PAS and 39 without, denoted as N-PAS) served as the training set, while another 47 patients (33 PAS and 14 N-PAS) constituted the validation set.
Background: Physical literacy (PL) can positively affect the health of children, adolescents, and adults, and is closely related to cardiorespiratory fitness (CRF).
Objective: To perform a systematic review and meta-analysis to examine the relationship between overall physical literacy (PL) and CRF in children and adolescents.
Methods: Cross-sectional, cohort and experimental studies on the relationship between PL and CRF in children and adolescents were collected by searching the Web of Science Core Collection, PubMed, EBSCOhost, ScienceDirect, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases.
Objective: Although belimumab has been widely used in patients with systemic lupus erythematosus (SLE) globally, real-world safety data among Chinese patients are limited, particularly for children. This study assessed the safety and tolerability of belimumab in adult and paediatric patients with SLE in China in real-world clinical practice.
Methods: This Phase 4, multicentre, prospective, observational study enrolled patients prescribed intravenous belimumab by their physicians in tertiary hospitals, independent of a clinical study, during routine clinical visits between May 2021 and May 2022.
Background: Atheroprotective shear stress preserves endothelial barrier function, while atheroprone shear stress enhances endothelial permeability. Yet, the underlying mechanisms through which distinct flow patterns regulate EC integrity remain to be clarified. This study aimed to investigate the involvement of Kindlin-2, a key component of focal adhesion and endothelial adherens junctions crucial for regulating endothelial cell (EC) integrity and vascular stability.
View Article and Find Full Text PDFClinical Effectiveness of Automated Coronary CT-derived Fractional Flow Reserve: A Chinese Randomized Controlled Trial.
Radiology
October 2024
Article Synopsis
- A multicenter randomized controlled trial in China investigated the impact of adding coronary CT-derived fractional flow reserve (CT-FFR) to routine coronary CT angiography (CCTA) on the need for invasive coronary angiography (ICA) and major adverse cardiovascular events (MACE) in patients with suspected coronary artery disease (CAD).
- The study involved 5,297 participants, showing that the CCTA plus CT-FFR group had a lower ICA rate (10.0%) compared to the CCTA alone group (12.4%) over a 90-day follow-up.
- While MACE rates were similar between groups, the CCTA plus CT-FFR approach resulted in fewer cardiac events after one year (0.5%
Article Synopsis
- The study aimed to compare gut microbiome and serum metabolic features between dust-exposed workers and healthy controls.
- Findings showed that the microbiome of dust-exposed workers had increased levels of Blautia and Trichoderma, along with changes in specific metabolites.
- The study suggests potential interactions between gut microbiome and metabolites that could impact silicosis progression, but it calls for more extensive research due to limitations like a small sample size.
Article Synopsis
- Zorifertinib is an experimental cancer drug that targets mutations in the EGFR gene and has shown effectiveness in patients with lung cancer that has spread to the brain.
- A phase 3 trial compared zorifertinib to standard treatments and found that it significantly extended the time patients lived without the disease worsening (progression-free survival).
- Results indicate that zorifertinib may be a better first-line treatment option for non-small cell lung cancer due to its ability to improve survival and manage side effects effectively.
Article Synopsis
- The research focuses on improving the diagnosis of subscapularis muscle injuries using artificial intelligence and magnetic resonance imaging (MRI) techniques, recognizing that these injuries are more common than previously thought.
- It involves a multicenter study with 384 patients, utilizing various MRI sequences to analyze the shoulder joint for accurate identification of injuries, employing advanced radiomic analysis for enhanced diagnostic precision.
- The ultimate goal is to refine preoperative assessments to potentially improve surgical outcomes and patient care in treating rotator cuff injuries.
Article Synopsis
- Cancer is the leading cause of death in adult dogs, with a significant chance (one-third) of developing it during their lifetime.
- A study using shallow whole-genome sequencing analyzed blood cell-free DNA from four dogs with tumors (one benign and three malignant) and 38 healthy dogs.
- Results showed that healthy dogs and the benign tumor dog had no copy number aberrations, while the malignant tumor dogs exhibited noticeable copy number variations and shorter DNA fragment sizes, indicating the potential for non-invasive cancer detection in dogs.
Background: Shotgun metagenomic next-generation sequencing (mNGS) is widely used to detect pathogens in bronchoalveolar lavage fluid (BALF). However, mNGS is complex and expensive. This study explored the feasibility of targeted next-generation sequencing (tNGS) in distinguishing lower respiratory tract infections in clinical practice.
View Article and Find Full Text PDFPurpose: To investigate the effectiveness and maintenance of perceptional learning (PL) on vision improvement in keratoconus (KC) patients corrected with spectacles.
Design: Randomized, double-blind clinical trial.
Methods: Non-progressive KC patients 9 years of age or older who had best spectacle-corrected distance visual acuity (CDVA) of 0 to 1.
Article Synopsis
- Exosome therapy has potential for heart repair after injury, but challenges like short lifespan and unclear targets limit its clinical use; the study introduces a new method called SCENT (stem cell-derived exosome nebulization therapy) for delivering exosomes through inhalation post-myocardial infarction (MI).
- Researchers tested SCENT in mice and pigs, finding it improves heart function, reduces tissue scarring, and promotes heart cell growth; advanced imaging techniques helped confirm these benefits.
- Mechanistic studies indicate that SCENT works by modifying the metabolism in endothelial cells, leading to better heart energy use, as seen in both mouse and pig models, showcasing its potential efficacy and safety for cardiac repair.
Article Synopsis
- The study investigates how retinal pigment epithelial (RPE) cells become active during proliferative vitreoretinopathy (PVR) after eye trauma, focusing on their rapid growth and changes.
- By examining chromatin accessibility and histone modifications in mouse models, the researchers map the epigenetic changes that correspond with the activation of specific genes associated with PVR.
- They identify potential treatments, including medications that inhibit enhancer activity and gene therapies, which could slow down PVR progression by targeting key molecular pathways.
Background: Despite endothelial dysfunction being an initial step in the development of hypertension and associated cardiovascular/renal injuries, effective therapeutic strategies to prevent endothelial dysfunction are still lacking. GPR183 (G protein-coupled receptor 183), a recently identified G protein-coupled receptor for oxysterols and hydroxylated metabolites of cholesterol, has pleiotropic roles in lipid metabolism and immune responses. However, the role of GPR183 in the regulation of endothelial function remains unknown.
View Article and Find Full Text PDFObjectives: To assess the predictive value of intratumoral and peritumoral radiomics based on Dual-energy CT urography (DECTU) multi-images for preoperatively predicting the muscle invasion status of bladder cancer (BCa).
Material And Methods: This retrospective analysis involved 202 BCa patients who underwent DECTU. DECTU-derived quantitative parameters were identified as risk factors through stepwise regression analysis to construct a DECT model.
A Brief Model Evaluated Outcomes After Liver Transplantation Based on the Matching of Donor Graft and Recipient.
Clin Transl Gastroenterol
January 2025
Article Synopsis
- Scientists wanted a better way to predict how well liver transplants work, so they created a new model that uses information from both donors and recipients.
- They tested this model with data from 528 patients and found that specific factors, like cold ischemia time (how long the liver was without blood) and a score called MELD, could help predict survival after the transplant.
- The new model, called the CIT-MELD Index (CMI), was found to be more effective than older methods at predicting outcomes and understanding the risks involved in liver transplants.
Article Synopsis
- Deep learning (DL) has the potential to enhance the diagnosis of cerebral aneurysms by utilizing large multicenter data sets for better segmentation and detection in CT angiography (CTA) images.
- A retrospective collection of CTA images from eight hospitals was used to develop and test a DL model, with performance assessed against radiology reports using the Dice similarity coefficient and receiver operating characteristic curves.
- The model demonstrated a high accuracy with a DSC of 0.87 for segmentation and 85.7% sensitivity in detecting aneurysms, performing comparably to traditional radiology assessments and processing scans relatively quickly in 1.76 minutes.