Publications by authors named "Y-L Feng"
Squamous cell carcinomas (SCC) are often preceded by potentially malignant precursor lesions, most of which remain benign. The terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) have been thoroughly characterized in established SCC. However, it is unclear what precancerous lesions harbor a bona fide high risk for malignant transformation and how precancerous epithelial dysplasia drives the immune system to the point of no return.
View Article and Find Full Text PDFThe androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription. The execution of growth-suppressive AR transcriptional programs in prostate cancer (PCa) and the potential for reactivation remain unclear.
View Article and Find Full Text PDFDCBLD1 Modulates Angiogenesis by Regulation of the VEGFR-2 Endocytosis in Endothelial Cells.
Arterioscler Thromb Vasc Biol
December 2024
Background: Unwanted angiogenesis is involved in the progression of various malignant tumors and cardiovascular diseases, and the factors that regulate angiogenesis are potential therapeutic targets. We tested the hypothesis that DCBLD1 (discoidin, CUB, and LCCL domain-containing protein 1) is a coreceptor of VEGFR-2 (vascular endothelial growth factor receptor-2) and modulates angiogenesis in endothelial cells.
Methods: A carotid artery ligation model and retinal angiogenesis assay were used to study angiogenesis using globe knockout or endothelial cell-specific conditional knockout mice in vivo.
Background And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.
Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.
Article Synopsis
- * Findings show that in 2021, the overall prevalence was 13.6%, with significantly higher rates for men (24.3%) compared to women (2.6%), and marked regional differences across the country.
- * Male sex, older age, and certain health conditions like hypertension and obesity are linked to higher hyperuricemia prevalence, highlighting the need for increased awareness and management of this issue in China's developed areas.
Article Synopsis
- Zorifertinib is an experimental cancer drug that targets mutations in the EGFR gene and has shown effectiveness in patients with lung cancer that has spread to the brain.
- A phase 3 trial compared zorifertinib to standard treatments and found that it significantly extended the time patients lived without the disease worsening (progression-free survival).
- Results indicate that zorifertinib may be a better first-line treatment option for non-small cell lung cancer due to its ability to improve survival and manage side effects effectively.
Article Synopsis
- This study aimed to evaluate long-term changes in Life's Essential 8 (LE8) components and their relationship with stroke risk in a large group of Chinese participants over a decade.
- Researchers tracked 26,719 individuals without prior stroke history, identifying five different trajectory patterns of LE8 from 2006 to 2016 and documenting nearly 500 stroke cases by 2020.
- Results showed that higher and more stable LE8 scores significantly reduced stroke risk, indicating that improved cardiovascular health can lessen stroke likelihood, even if starting levels were low.
Article Synopsis
- The BAD-study was a comprehensive analysis of branch atheromatous disease (BAD)-related strokes in 476 patients across 20 hospitals in China, focusing on demographic, clinical, and therapeutic aspects.
- The study found that the majority of participants were middle-aged and male, with a higher occurrence of strokes linked to the lenticulostriate artery; 86.5% of patients had good outcomes by 90 days, despite 14.7% experiencing early neurological deterioration.
- Key predictors of poor outcomes included higher stroke severity at admission and early deterioration, while extracranial artery stenosis was associated with better outcomes.
Hypothesis: Microneedle-mediated intracochlear injection of siRNA-Lipofectamine through the round window membrane (RWM) can be used to transfect cells within the cochlea.
Background: Our laboratory has developed 100-μm diameter hollow microneedles for intracochlear injection through the guinea pig RWM. In this study, we test the feasibility of microneedle-mediated injection of siRNA and Lipofectamine, a commonly used reagent with known cellular toxicity, through the RWM for cochlear transfection.
Article Synopsis
- Coronary computed tomography angiography (CCTA) can help assess the difficulty of performing percutaneous coronary interventions (PCI) in patients with chronic total occlusion (CTO) by analyzing plaque characteristics through radiomics.
- The study involved 551 patients, and the developed radiomics model demonstrated a higher predictive ability for guidewire success than existing models, showing an area under the curve (AUC) of 0.86 in external testing.
- The effectiveness of the radiomics model relies on factors like the presence of calcification, the location of the CTO, the involvement of adjacent branches, and the experience level of the operators performing the procedure.
Background: Stroke etiology could influence the outcomes in patients with basilar-artery occlusion (BAO). This study aimed to evaluate the differences in efficacy and safety of best medical treatment (BMT) plus endovascular treatment (EVT) versus BMT alone in acute BAO across different stroke etiologies.
Methods: The study was a post hoc analysis of the ATTENTION trial (Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion), which was a multicenter, randomized trial at 36 centers in China from February 2021 to September 2022.
Article Synopsis
- Preoperative local-regional tumor staging for gastric cancer is essential for effective treatment planning, and a study aimed to compare the accuracy of multiparametric MRI (mpMRI) and dual-energy CT (DECT) in this context.
- The research involved 202 patients undergoing both imaging techniques before surgery, with diagnostic accuracy evaluated by six radiologists against the surgical specimens as the reference standard.
- Results indicated that mpMRI outperformed DECT in T staging, while also providing equal or better accuracy in N staging, highlighting its potential as a more reliable imaging option for gastric cancer patients.
Article Synopsis
- Scientists are trying to figure out why some cancers don't respond well to chemotherapy, which is medicine that fights cancer.
- They used a special tool called CRISPR to study how different cancer cells react to seven different cancer drugs.
- The researchers found that even though cancers can develop resistance in different ways, there's a specific target, called PLK4, that could help overcome this resistance and improve treatment.
Purpose: To assess the consistencies of anti-Toxocara IgG (T-IgG) and Goldmann-Witmer coefficient (GWC) between paired aqueous humor (AH) and vitreous samples from patients with clinically suspected ocular toxocariasis (OT).
Design: Inter-test reliability assessment.
Methods: A total of 47 patients with clinically suspected OT who underwent vitrectomy were included.
Article Synopsis
- - The study focused on the ability of deep learning models using CT scans to tell apart benign and malignant small pulmonary nodules (SPNs) that are 8 mm or smaller.
- - Researchers developed and tested multiple models, finding that Model 4 was the most effective in distinguishing between benign and malignant SPNs, outperforming traditional algorithms.
- - Ultimately, the study suggests that these CT-based deep learning models are reliable tools for identifying the nature of small pulmonary nodules, which can aid in better diagnosis and treatment.
Purpose: Although effective amblyopia treatments are available, treatment outcome is unpredictable, and the condition recurs in up to 25% of the patients. We aimed to evaluate whether a large-scale quantitative contrast sensitivity function (CSF) data source, coupled with machine learning (ML) algorithms, can predict amblyopia treatment response and recurrence in individuals.
Methods: Visual function measures from traditional chart vision acuity (VA) and novel CSF assessments were used as the main predictive variables in the models.
As immunotherapy makes its way into the perioperative setting, a growing number of clinical trials are expanding the evidence base for resectable non-small cell lung cancer (NSCLC) management. Identifying the optimal treatment pattern-whether it's neoadjuvant, adjuvant, or a combination of both-is a crucial next step, particularly in pinpointing which patients benefit the most. This decision-making process requires a multi-disciplinary treatment team capable of utilizing tissue and plasma genomic testing to inform therapeutic choices.
View Article and Find Full Text PDFArticle Synopsis
- Glycoursodeoxycholic acid (GUDCA) has been shown to help with metabolic disorders and has now been studied for its potential effects on reducing arterial thrombosis, with an aim to understand its mechanisms.
- The research involved analyzing GUDCA levels in patients and diet-induced obese mice, using various models to assess its impact on platelet function and thrombosis while also studying lipid changes in platelets after GUDCA treatment.
- Results indicated that lower GUDCA levels are linked to higher thrombosis risk and that GUDCA significantly reduces platelet activity and thrombogenesis by inhibiting diacylglycerol kinase (DGK), suggesting that it could be beneficial for managing thrombosis, particularly in obese individuals.
Unlabelled: African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and infection. By engineering CRISPR-Cas systems to target nine specific loci within the ASFV genome, we observed a substantial reduction in viral replication .
View Article and Find Full Text PDFNorepinephrine (NE) is an essential biogenic monoamine neurotransmitter. The first-generation NE sensor makes in vivo, real-time, cell-type-specific and region-specific NE detection possible, but its low NE sensitivity limits its utility. Here, we developed the second-generation GPCR-activation-based NE sensors (GRAB and GRAB) with a superior response and high sensitivity and selectivity to NE both in vitro and in vivo.
View Article and Find Full Text PDFBackground: Current replacement procedures for stenosis or occluded arteries using prosthetic grafts have serious limitations in clinical applications, particularly, endothelialization of the luminal surface is a long-standing unresolved problem.
Method: We produced a cell-based hybrid vascular graft using a bioink engulfing adipose-derived mesenchymal stromal cells (ADSCs) and a 3D bioprinting process lining the ADSCs on the luminal surface of GORE-Tex grafts. The hybrid graft was implanted as an interposition conduit to replace a 3-cm-long segment of the infrarenal abdominal aorta in Rhesus monkeys.
Article Synopsis
- The respiratory system, particularly the lungs, is significantly affected by SARS-CoV-2, and conventional antibody delivery methods have limitations for treating infections in this area.
- Researchers have identified a human monoclonal antibody, 8-9D, that can effectively neutralize various SARS-CoV-2 variants, particularly through its unique structural features.
- By using a specialized mRNA delivery approach, the study shows that lung-targeted delivery of 8-9D mRNA leads to the production of protective antibodies in the lungs, successfully preventing severe infections in a mouse model.
Article Synopsis
- Scientists are using a special tool called paired Cas9 nickases (Cas9n) to edit genes, which helps reduce mistakes.
- They found that a protein called TREX2 can help improve the success of this gene editing when they deal with tricky parts called 3'-overhanging ends.
- By teaming up TREX2 with Cas9n, they made the editing process safer and more efficient, making it easier to change genes for various purposes.
Importance: Gastrointestinal injury progression induced by antiplatelet therapy in patients after percutaneous coronary intervention (PCI) has not been well studied.
Objective: To assess the association of aspirin, clopidogrel, and their combination with gastrointestinal injury progression among patients without high bleeding risk after PCI.
Design, Setting, And Participants: This secondary analysis assessed data from the Optimal Antiplatelet Therapy for Prevention of Gastrointestinal Injury Evaluated by ANKON Magnetically Controlled Capsule Endoscopy (OPT-PEACE) double-masked, placebo-controlled, multicenter randomized clinical trial.