Publications by authors named "Y-D Chuang"
Introduction: The prospective study aimed to investigate the long-term associated risks of cirrhosis and hepatocellular carcinoma (HCC) across various subtypes of steatotic liver disease (SLD).
Methods: We enrolled 332,175 adults who participated in a health screening program between 1997 and 2013. Participants were categorized into various subtypes, including metabolic dysfunction-associated SLD (MASLD), MASLD with excessive alcohol consumption (MetALD), and alcohol-related liver disease (ALD), based on ultrasonography findings, alcohol consumption patterns, and cardiometabolic risk factors.
Background: The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.
Methods: We conducted a multiancestry whole-genome sequencing analysis of blood pressure among 51 456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program participants (stage-1). Stage-2 analyses leveraged array data from UK Biobank (N=383 145), Million Veteran Program (N=318 891), and Reasons for Geographic and Racial Differences in Stroke (N=10 643) participants, along with whole-exome sequencing data from UK Biobank (N=199 631) participants.
Article Synopsis
- This study investigates the link between plasma lipids (like triglycerides and LDL/HDL cholesterol) and microvascular complications (kidney disease and retinopathy) in 2,535 individuals with type 2 diabetes over a 14-year period.
- Results show that higher triglyceride levels are significantly associated with an increased risk of diabetic kidney disease, while higher HDL cholesterol is linked to a reduced risk.
- The findings suggest that targeting lipid levels, particularly triglycerides and HDL cholesterol, could be beneficial in the management and treatment of diabetic kidney disease, although the link with retinopathy was less clear.