Study of platelet activation, hypercoagulable state, and the association with pulmonary hypertension in children with β-thalassemia.

Background: The increased survival rate of thalassemic patients has led to unmasking of management related complications which were infrequently encountered.

Objective: Study the increased coagulation and platelet activation in children with β-thalassemia, to analyze the factors that lead to such hypercoagulable state and to study pulmonary hypertension (PH) in conjunction with platelet activation and hypercoagulable state in children with β-thalassemia.

Methods: 36 Egyptian children with β-thalassemia with a mean age of 9.

Clinico-epidemiology of neuroblastoma in north east Egypt: A 5-year multicenter study.

Neuroblastoma, an embryonal malignancy of the sympathetic nervous system, is the most frequent extracranial solid tumor The clinico-epidemiological features of neuroblastoma in infants and children were investigated between January 2005 and January 2010 at the Pediatric Oncology units of Mansoura, Zagazig, and Tanta University Children's Hospitals (Egypt). Of 142 cases of neuroblastoma, 10 were omitted from the study due to defective data. The median age of the patients was 30 months, with 75.

Assessment of Myocardial Function in Children before and after Autologous Peripheral Blood Stem Cell Transplantation.

Background: Increased interest is focused on the long-term adverse effects of bone marrow transplantation. Subclinical cardiac involvement appears common in adults, but only a few reports have examined pediatric patients.

Materials And Methods: A prospective case-control study of 19 children with normal cardiac function undergoing autologous hematopoietic stem cell transplantation (HSCT) was performed.

Spectrum of Beta Globin Gene Mutations in Egyptian Children with β-Thalassemia.

Background: The molecular defects resulting in a β-thalassemia phenotype, in the Egyptian population, show a clear heterogenic mutations pattern. PCR-based techniques, including direct DNA sequencing are effective on the molecular detection and characterization of these mutations. The molecular characterization of β-thalassemia is necessary for carrier screening, genetic counseling, and to offer prenatal diagnosis.