THE MORPHOLOGICAL PICTURE OF LOCAL IMMUNE RESPONSES IN THE KIDNEYS, URETERS AND BLADDER OF THE FOETUSES AND NEWBORNS, WHO DEVELOPED IN CONDITIONS OF MATERNAL PREECLAMPSIA.

The purpose of the research consisted in revealing morphological peculiarities of local immune responses in the kidneys, ureters and bladder of the foetuses and newborns, who developed in conditions of maternal preeclampsia with different degrees of its severity. The research was conducted on autopsy material: the kidneys, ureters and bladders of mature foetuses and newborns. Four groups were formed in the study: group I - foetuses and newborns from mothers with physiological pregnancy; group II - foetuses and newborns from mothers, whose pregnancy was complicated with a mild degree of preeclampsia; group III - foetuses and newborns from mothers, whose pregnancy was complicated with a moderately severe degree of preeclampsia; group IV - foetuses and newborns from mothers, whose pregnancy was complicated with severe preeclampsia.

[PATHOGENICALLY INDUCED APOPTOSIS CAUSED BY HYPOXIC EFFECTS IN THE URINARY SYSTEM ORGANS OF FETUSES AND NEWBORNS (EXPERIMENTAL STUDY)].

The purpose of the study was to identify the characteristics of apoptosis in the kidneys, ureters and bladder of fetuses and newborns in the modeling of chronic intrauterine hypoxia, acute postnatal hypoxia and mixed hypoxia. An experiment was conducted on WAG rats for modeling high altitude hypoxia. Experimental animals were divided into four groups: I - control - fetuses and newborns from healthy rats; II - modeling of chronic intrauterine hypoxia; III - modeling of acute postnatal hypoxia; IV - modeling of mixed hypoxia.

Role of Adenohypophysotropic Neurohormones in Endocrine Paraadenohypophysial Regulation of Peripheral Target Organs in Rat Ontogeny.

We tested the hypothesis that brain-derived chemical stimuli contribute to direct endocrine regulation of peripheral organs during ontogeny before blood-brain barrier closure. Dopamine and gonadotropin-releasing hormone present in high concentration in peripheral blood only before blood-brain barrier closure were chosen as the chemical stimuli. It was shown than dopamine in concentrations equal to its level in the peripheral blood inhibits prolactin secretion in organotypic culture of the pituitary gland from newborn rats via specific receptors.