Cytotoxicity of the Sesquiterpene Lactones, Ivalin and Parthenolide in Murine Muscle Cell Lines and Their Effect on Desmin, a Cytoskeletal Intermediate Filament.

Vermeersiekte or "vomiting disease" is an economically important disease of ruminants following ingestion of () species in South Africa. Sheep are more susceptible, and poisoning is characterized by stiffness, regurgitation, bloat, paresis, and paralysis. Various sesquiterpene lactones have been implicated as the cause of poisoning.

Sesquiterpene lactones from Harv. and their cytotoxicity.

poisoning, referred to as 'vermeersiekte' is an important plant poisoning in southern Africa. Three sesquiterpene lactones, isogeigerin acetate () ivalin () and geigerin () were isolated and purified from Harv. (Asteraceae).