Publications by authors named "Y Zaizen"
The degree of exercise-induced oxygen desaturation and outcomes following antifibrotic drug therapy in asymptomatic patients with fibrosing interstitial lung disease (FILD) remain unclear. We compared clinical data, incidence of annual FILD progression, overall survival, and tolerability after initiating nintedanib between 58 patients with dyspnea and 18 patients without. Annual FILD progression was defined as >10% decrease in forced vital capacity (FVC), >15% decrease in diffusing capacity of the lungs for carbon monoxide (D), developing acute exacerbations, or FILD-related death within 1 year of starting nintedanib.
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- The study aimed to identify prognostic factors for annual progression in mild fibrosing interstitial lung disease (FILD) using retrospective data and logistic regression analysis.
- Significant factors associated with progression included the diagnosis of specific lung diseases, patient-reported outcomes, changes in lung function tests, and the CT scan's appearance.
- The findings suggest that factors such as exercise-induced hypoxia, radiological patterns, and certain disease diagnoses are key predictors of how FILD may worsen over time.
Viral double-stranded RNA (dsRNA) is sensed by toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including melanoma differentiation-associated gene 5 (MDA5). MDA5 recognizes the genome of dsRNA viruses and replication intermediates of single-stranded RNA viruses. MDA5 also plays an important role in the development of autoimmune diseases, such as Aicardi-Goutieres syndrome and type I diabetes.
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- An 82-year-old man with a previous diagnosis of interstitial lung disease received a bivalent mRNA COVID-19 vaccine and developed respiratory issues 1.5 months later.
- High-resolution CT scans showed new lung abnormalities, leading to a transbronchial lung cryobiopsy that identified acute lung injury and fibrosis.
- The patient's condition was confirmed as an acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), with the vaccine being linked as the cause; he improved following high-dose corticosteroid treatment.