Publications by authors named "Y Zaitsu"
Purpose: This study aimed to investigate the efficacy of measuring lymph node size on preoperative CT imaging to predict pathological lymph node metastasis in patients with colon cancer to enhance diagnostic accuracy and improve treatment planning by establishing more reliable assessment methods for lymph node metastasis.
Methods: We retrospectively analyzed 1,056 patients who underwent colorectal resection at our institution between January 2004 and March 2020. From this cohort, 694 patients with resectable colon cancer were included in the study.
Background: Signal regulatory protein alpha (SIRPα) inhibits phagocytosis by macrophages by interacting with CD47. Despite its known role in various cancers, the clinical significance of SIRPα in gastric cancer (GC) remains unclear. This study aimed to elucidate the clinical implications of SIRPα in GC, exploring its relevance to immunotherapy efficacy and the tumor microenvironment.
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- The management of colorectal liver metastases (CRLMs) requires a team approach, with debates over the use of angiogenesis inhibitors for RAS mutant tumors.
- A case study of a 37-year-old woman with RAS mutant transverse colon cancer showed long-term disease-free survival through multiple surgeries and the combination treatment of aflibercept and FOLFIRI.
- The findings suggest that a multidisciplinary strategy focused on complete tumor resection, along with the use of aflibercept, can successfully manage recurrent CRLMs and offer extended survival rates.
Article Synopsis
- This study investigates how the surgical margins (the amount of healthy tissue around a tumor) affect the likelihood of colon cancer coming back after surgery.
- It analyzed data from 579 patients with resectable colon cancer to determine if longer resection margins lead to better relapse-free survival (RFS).
- The findings suggest that for patients with pT4 colon cancer, a margin of at least 7 cm reduces the risk of recurrence compared to shorter margins.
Background/aim: The efficacy of neoadjuvant chemotherapy (NAC) for colon cancer remains unestablished. This study aimed to investigate the outcomes of NAC in patients with locally advanced T4b or obstructive T4a colon cancers (LACC).
Patients And Methods: Data of patients with LACC who underwent colon surgery between 2010 and 2022 after NAC at our institution were retrospectively reviewed.