The Role of AIM2 in Cancer Development: Inflammasomes and Beyond.

Absence in melanoma 2 (AIM2) protein functions as a double-stranded DNA sensor and is critical for host defense against intracellular bacterial and viral pathogens. Recent research has highlighted the significance of AIM2 in the pathogenesis of diverse malignancies. Through its recognition of foreign or intracellular dsDNA, AIM2 triggers inflammasome activation, resulting in the release of pro-inflammatory cytokines such as IL-1β, IL-18, and induction of pyroptosis.

Sliding ferroelectric memories and synapses based on rhombohedral-stacked bilayer MoS.

Recent advances have uncovered an exotic sliding ferroelectric mechanism, which endows to design atomically thin ferroelectrics from non-ferroelectric parent monolayers. Although notable progress has been witnessed in understanding the fundamental properties, functional devices based on sliding ferroelectrics remain elusive. Here, we demonstrate the rewritable, non-volatile memories at room-temperature with a two-dimensional (2D) sliding ferroelectric semiconductor of rhombohedral-stacked bilayer MoS.

Recent methane surges reveal heightened emissions from tropical inundated areas.

Record breaking atmospheric methane growth rates were observed in 2020 and 2021 (15.2±0.5 and 17.

Effects of the Vivifrail-B multicomponent exercise program based on society ecosystems theory on physical function in community-dwelling frail older adults: A randomized controlled trial.

Objective: The study aimed to explore the short and long-term effects of the Vivifrail-B multicomponent exercise based on society ecosystems theory on physical function in community-dwelling frail older adults.

Methods: 59 older adults were randomly assigned to the intervention (n = 30) and control (n = 29) groups. The exercise was performed thrice a week for 12 weeks, with one offline group training and two at home training.

Evaluation of wheat drought resistance using hyperspectral and chlorophyll fluorescence imaging.

Photosynthesis drives crop growth and production, and strongly affects grain yields; therefore, it is an ideal trait for wheat drought resistance breeding. However, studies of the negative effects of drought stress on wheat photosynthesis rates have lacked accurate evaluation methods, as well as high-throughput techniques. We investigated photosynthetic capacity under drought stress in wheat varieties with varying degrees of drought stress resistance using hyperspectral and chlorophyll fluorescence (ChlF) imaging data.