Publications by authors named "Y Z Lun"
Hespintor Negative Regulation of PI3K/Akt Pathway Induces Cell Cycle Arrest of Hepatocellular Carcinoma.
Bull Exp Biol Med
January 2025
The mechanism of Hespintor (a protein of serpin family) inhibitory action on the growth of inoculated hepatocellular carcinoma was studied in a model of human hepatoma in nude mice by using on long-noncoding RNA (lncRNA) sequencing. Two days after tumor transplantation, Hespintor or normal saline was injected into the caudal vein at a dose of 15 μg/kg (2 times a week over 4 weeks). The tumors were isolated in 4 weeks after subcutaneous injection of human hepatoma MHCC97-H cells.
View Article and Find Full Text PDFPurpose: This study explored the clinical characteristics of patients with tinnitus who responded to sound therapy and established a predictive model to evaluate the effectiveness of this therapy according to the clinical characteristics.
Methods: A retrospective analysis was performed on 991 subjective tinnitus patients who received compound sound therapy in the Department of Otolaryngology of the local hospital from November 2019 to January 2022.
Results: We found that tinnitus patients with different therapeutic effects had significant differences in the tinnitus side ( = 0.
Importance: Poor medication adherence is associated with high morbidity and mortality among patients with chronic heart failure (CHF), which is particularly concerning in China.
Objective: To assess the effect of a pharmacist-led management model incorporating a social media platform vs usual care on medication adherence in patients with CHF.
Design, Setting, And Participants: This prospective, multicenter randomized clinical trial was conducted from March 2021 to May 2023, with a follow-up duration of 52 weeks.
Background: In the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression, and consequently imposing a greater economic burden on the healthcare system.
Objectives: Our objective was to examine the impact of pharmacogenomic testing on medication adherence and antidepressant switching rates among individuals diagnosed with depression.
Article Synopsis
- Advanced carotid atherosclerotic plaques increase the risk of ischaemic stroke, making it crucial to understand the immune cell characteristics and biomarkers linked to plaque progression.
- Our research used single-cell RNA sequencing and advanced analysis techniques to identify a specific subcluster of monocytes that are more prevalent in advanced plaques and found effective ways to distinguish between early and advanced stages of plaque.
- We developed a deep learning model based on gene-immune interactions that showed high accuracy in diagnosing advanced plaques, which highlights the importance of unique monocyte populations for clinical diagnostic tool development.