Publications by authors named "Y Yumoto"
Background: Addressing the limited access to treatments for alcohol dependence, we developed ALM-002, a therapeutic application to be "prescribed" for non-abstinence-oriented treatment in internal medicine settings. Our objective was to preliminarily assess the efficacy and safety of ALM-002.
Methods: In a multicenter, open-label randomized controlled trial, participants aged ≥20 with alcohol dependence and daily alcohol consumption exceeding 60 g for men and 40 g for women, without severe complications, were randomly assigned to either the intervention group using ALM-002 or the treatment-as-usual control group.
Article Synopsis
- The study aimed to understand how specific genetic variants related to alcohol metabolism (ADH1B*2 and ALDH2*2) influence alcohol dependence (AD) in East Asians, particularly Japanese men.
- Results showed that individuals with the ADH1B*1/*1 and ALDH2*1/*1 genotypes experienced alcohol-related issues like blackouts and withdrawal symptoms at younger ages compared to those with other genotypes.
- The findings indicated that while certain genotypes accelerated the onset and severity of drinking problems, the flushing response to alcohol had a minimal impact on these drinking events.
Article Synopsis
- In early drug discovery, assessing drug-drug interactions (DDIs) is crucial for understanding how new drug candidates may affect each other's metabolism.
- CYP3A activators can lead to inaccurate assessments of DDIs by specifically impacting the metabolism of midazolam in certain ways.
- The developed CYP cocktail inhibition assay simultaneously evaluates CYP3A activation and inhibition, making it an efficient tool for identifying potential DDIs in the initial phases of drug development.
Aims: Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this report, the effects of KPR-5714, which is a selective transient receptor potential melastatin 8 (TRPM8) antagonist, on bladder overactivity induced by water avoidance stress were examined.
View Article and Find Full Text PDFExhaled gas analysis is a non-invasive test ideal for continuous monitoring of biological metabolic information. We analyzed the exhaled gas of patients with inflammatory diseases for trace gas components that could serve as biomarkers that enable early detection of inflammatory diseases and assessment of treatment efficacy. Furthermore, we examined the clinical potential of this method.
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