Publications by authors named "Y Yuki"
Article Synopsis
- Natural killer (NK) cells interact with diseased and foreign cells through specific receptors (NKG2A/HLA-E and KIR/HLA-ABC), which may play a role in kidney transplant pathology independent of antibodies.
- A study using CyTOF identified diverse NK cell subsets in transplant recipients, with NKG2A+KIR+ NK cells showing a particularly strong response that continued post-transplant despite immunosuppressive treatment.
- The release of a cytotoxicity mediator, Ksp37, by NKG2A+ NK cells before transplantation was linked to poorer long-term kidney function, suggesting a potential role for analyzing Ksp37 as a biomarker for transplant
Vaccine-elicited T cell responses can contribute to immune protection against emerging infectious disease risks such as antimicrobials-resistant (AMR) microbial pathogens and viruses with pandemic potential, but rapidly identifying appropriate targets for T cell priming vaccines remains challenging. Mass spectrometry (MS) analysis of peptides presented on major histocompatibility complexes (MHCs) can identify potential targets for protective T cell responses in a proteome-wide manner. However, pathogen-derived peptides are outnumbered by self peptides in the MHC repertoire and may be missed in untargeted MS analyses.
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- Sapovirus (SaV) infections are on the rise globally, with a notable increase in Japan from 2010 to 2022, mainly due to the GI.1 genotype.
- The study analyzed 15 SaV GI.1 outbreak strains using next-generation sequencing and found distinct clustering in lineages and specific amino acid substitutions in their genomes.
- Key mutations associated with the pathogenicity and spread of SaV were identified in strains responsible for the largest outbreak in Japan (2021-2022), enriching the understanding of SaV's genetic makeup.
class I variation has the strongest effect genome-wide on outcome after HIV infection, and as such, an understanding of the impact of polymorphism on response to HIV vaccination may inform vaccine design. We sought associations with HIV-directed immunogenicity in the phase 1/2a APPROACH vaccine trial, which tested vaccine regimens containing mosaic inserts in Ad26 and MVA vectors, with or without a trimeric gp140 protein. While there were no allelic associations with the overall cellular immune response to the vaccine assessed by ELISpot (Gag, Pol, and Env combined), significant associations with differential response to Gag compared to Env antigens were observed.
View Article and Find Full Text PDFAlthough natural killer (NK) cells are recognized for their modulation of immune responses, the mechanisms by which human NK cells mediate immune regulation are unclear. Here, we report that expression of human leukocyte antigen (HLA)-DP, a ligand for the activating NK cell receptor NKp44, is significantly upregulated on CD8 effector T cells, in particular in human cytomegalovirus (HCMV) individuals. HLA-DP CD8 T cells expressing NKp44-binding HLA-DP antigens activate NKp44 NK cells, while HLA-DP CD8 T cells not expressing NKp44-binding HLA-DP antigens do not.
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