Age-dependent differences in the efficacy of cancer immunotherapy in C57BL and AKR mouse strains.

While tumor incidence increases with age, tumor growth and metastasis often proceed at a slower rate in aged organisms. The mechanisms underlying this age-related reduced tumor development may suggest therapeutic modalities appropriate for the aged. Decreased tumor aggressiveness in the old was shown to be related to altered immune response.

Increased salivary interleukin-6 levels in patients with primary Sjögren's syndrome.

This study's purpose was to evaluate salivary interleukin-6 (IL-6) levels in patients with primary Sjögren's syndrome (SS). Salivary and serum IL-6 concentrations were evaluated by ELISA in 36 patients with SS and compared with 19 patients complaining of dry mouth and with normal controls. Salivary IL-6 levels were significantly elevated (P < 0.

Colonic metastases from lobular carcinoma of the breast. Report of a case.

Metastatic involvement of the gastrointestinal tract secondary to breast cancer is rare. A case of diffuse infiltration of the colon by metastatic infiltrating lobular breast cancer is reported. Awareness of this condition may lead to proper investigations including intestinal biopsy, thus avoiding unnecessary surgery.