Publications by authors named "Y Yoshitomi"

Aim: This study aimed to evaluate the impact of long-term exposure to physical barriers used as preventive measures during the coronavirus disease 2019 (COVID-19) pandemic on cognitive function and behavior in an apolipoprotein E (ApoE) mouse dementia model.

Methods: ApoE mice were divided into co-housed, partitioned by a transparent bulkhead (partitioned), and isolated groups. To assess anxiety, cognitive recognition, and spatial learning, behavioral tests, including the open-field test, novel object recognition test, and Morris water maze test, were conducted at three and six months after the start of the 33-week rearing period.

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  • A study evaluated an AI model's ability to predict elevated brain natriuretic peptide (BNP) levels from chest radiograms, focusing on its impact on healthcare professionals' diagnostic accuracy.
  • The AI model was developed using data from over 8,000 chest images and demonstrated high performance metrics, including an accuracy of 85.5% and a receiver-operating-characteristics area-under-curve score of 0.929.
  • Results showed that the AI assistance significantly improved diagnostic accuracy for both experienced and early-career healthcare professionals, with early-career professionals outperforming veterans when using the AI tool.
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  • HIV-associated Kaposi's sarcoma (HIV-KS) is a tumor linked to HHV-8 infection, typically treatable with antiretroviral therapy (ART) and chemotherapy, though some cases resist treatment.
  • A 58-year-old man with refractory HIV-KS faced complications after chemotherapy, which caused painful lesions that affected his ability to walk.
  • Localized radiotherapy was used to treat his condition after ruling out metastases, leading to significant improvements in both appearance and mobility, suggesting a promising alternative for patients not responding to standard treatments.
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Multiple studies have reported the use of perifascial areolar tissue (PAT) grafts to treat wounds involving exposed ischemic tissues, avascular structures, and defective membrane structures. Our objective was to assess the quantitative effects of PAT grafts and their suitability for wounds with ischemic tissue exposure and to qualitatively determine the factors through which PAT promotes wound healing and repair. We conducted histological, immunohistochemical, and mass spectrometric analyses of the PAT grafts.

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