Publications by authors named "Y Yasunaga"
Purpose: This multi-institutional observational study aimed to assess the incidence, severity, and impact of radiotherapy-related late toxicities of the cervical skin and soft tissue in head and neck cancer patients. We also explored patient interest in fat grafting as a potential treatment for skin and soft tissue sequelae.
Methods: This study was conducted across 19 institutions in Japan.
Article Synopsis
- Fibrous dysplasia (FD) is mostly symptomless but can lead to rare neurological issues, like abducens nerve palsy, particularly in older patients.
- A case was reported involving a 76-year-old woman who developed left abducens nerve palsy due to pressure from an FD-related cyst, which was successfully treated through endoscopic surgery.
- The case highlights that while FD usually affects younger individuals, it can cause serious complications such as nerve palsy in older patients, especially when cysts form and create pressure that necessitates surgical intervention.
Article Synopsis
- The study analyzed the effectiveness of whole genome sequencing (WGS) compared to whole exome sequencing (WES) in identifying driver alterations in cancer genomes, given that WES missed these changes in 27.8% of cases.
- Researchers focused on 177 cancer samples previously classified as "driverless" by WES, finding that WGS successfully identified driver and likely driver alterations in 68.4% and 22.6% of those samples, respectively.
- The most common genomic changes detected by WGS included oncogene amplification and tumor suppressor gene deletions, highlighting the significance of WGS in uncovering genetic alterations linked to tumor development.
Article Synopsis
- This study on pancreatic neuroendocrine tumors (PanNETs) explores the use of biomarkers like DAXX/ATRX and H3K36me3 alongside traditional factors like WHO grade and tumor size to predict recurrence risk after surgery.
- Researchers found that 16.2% of primary PanNETs had losses of DAXX or ATRX, indicating a higher risk of recurrence and correlating better with postoperative outcomes than WHO grade.
- A new risk stratification algorithm was proposed, categorizing patients into very low-risk, low-risk, and high-risk groups based on DAXX/ATRX status and tumor characteristics, while also addressing the variability of expression patterns in different tumors.
Lateral chest wall perforator flaps, such as the lateral intercostal artery perforator flap, lateral thoracic artery perforator flap, and thoracodorsal artery perforator flap, have been used for volume replacement oncoplastic breast-conserving surgery (VR-OPBCS) in the lateral and central breast. However, there are cases in which these perforators are missing or too thin, making it difficult to raise a flap for partial breast reconstruction. A 58-year-old woman underwent VR-OPBCS for breast cancer in the lower quadrant of the right breast.
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