A 2OGD multi-gene cluster encompasses functional and tissue specificity that direct furanocoumarin and pyranocoumarin biosynthesis in citrus.

Furanocoumarins (FCs) are plant defence compounds derived from the phenylpropanoid pathway via the coumarin umbelliferone that harbour some therapeutic benefits yet are the underlying cause of 'grapefruit-drug interactions' in humans. Most of the pathway genes have not been identified in citrus. We employed a genetic/Omics approach on citrus ancestral species and F1 populations of mandarin × grapefruit and mandarin × pummelo.

LieRHRV system for remote lie detection using heart rate variability parameters.

The standard polygraph, or lie detector, is limited by its reliance on average heart rate, subjective examiner interpretation, and the need for direct subject contact. Remote photoplethysmography (rPPG) offers a promising contactless alternative, by using facial videos to extract heart rate variability (HRV). We introduce "LieRHRV," a remote lie detection algorithm based solely on extracted HRV parameters.

Computational insight into energy control balance by Ca and cAMP-PKA signaling in pacemaker cells.

Cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling controls sinoatrial node cell (SANC) function by affecting the degree of coupling between Ca and membrane clocks. PKA is known to phosphorylate ionic channels, Ca pump and release from the sarcoplasmic reticulum, and enzymes controlling ATP production in the mitochondria. While the PKA cytosolic targets in SANC have been extensively explored, its mitochondrial targets and its ability to maintain SANC energetic balance remain to be elucidated.