Publications by authors named "Y Y Yau"
Objectives: Restorative neurostimulation for multifidus muscle is a novel therapy for chronic low back pain (CLBP). Optimal outcomes require interdisciplinary follow-up. We describe a clinical care pathway (CPW) for this therapy and report patient compliance, clinical outcomes, and patient satisfaction with the CPW.
View Article and Find Full Text PDFCoastal ecosystems play a major role in marine carbon budgets, but substantial uncertainties remain in the sources and fluxes of coastal carbon dioxide (CO). Here, we assess when, where, and how submarine groundwater discharge (SGD) releases CO to shallow coastal ecosystems. Time-series observations of dissolved CO and radon (Rn, a natural groundwater tracer) across 40 coastal systems from 14 countries revealed large SGD-derived CO fluxes.
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- Mitochondrial trifunctional protein deficiency is a disorder affecting long-chain fatty acid metabolism, leading to severe heart issues like cardiomyopathy and arrhythmias.
- Triheptanoin, a synthetic medium-chain triglyceride, has shown potential to improve cardiomyopathy in some cases, although research is limited for severe presentations.
- A case is presented of a newborn with severe disease who did not improve despite receiving mechanical support and triheptanoin treatment.
Article Synopsis
- Restorative neurostimulation of the lumbar multifidus muscle shows promise as a treatment option for chronic low back pain (CLBP) in patients who have previously undergone lumbar surgery, a group often excluded from studies.
- In a case series of 26 patients, significant improvements were observed in low back pain scores and disability indices over 12 months, with 40% achieving clinically important improvements.
- Patient satisfaction rates were high, and there were minimal adverse events, indicating that this therapy may be safe and effective for those with prior lumbar surgery.
Over the course of the COVID-19 pandemic, variants have emerged with increased mutations and immune evasive capabilities. This has led to breakthrough infections (BTI) in vaccinated individuals, with a large proportion of the neutralizing antibody response targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike glycoprotein. Immune imprinting, where prior exposure of the immune system to an antigen can influence the response to subsequent exposures, and its role in a population with heterogenous exposure histories has important implications in future vaccine design.
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