Research Progress on Glycolysis Mechanism of Psoriasis.

Psoriasis is a chronic inflammatory disease with a complex pathogenesis. Hyperplasia of glycolytic-dependent epidermal keratinocytes (KCs) is a new hallmark of psoriasis pathogenesis. Meanwhile, immune cells undergo metabolic reprogramming similar to KCs.

Exploring the interaction mechanism between the programmed death-ligand 1 protein and scutellarin via multi-spectroscopy and computer simulation.

The programmed death-ligand 1 (PD-L1) protein plays a key role in immune responses. Scutellarin (SCU), as a flavonoid, has a variety of bioactivities. In this study, the human PD-L1 was obtained by expression and purification, and the interaction mechanisms between PD-L1 and SCU were revealed through multi-spectroscopy and computer simulation.

Automatic segmentation of white matter lesions on multi-parametric MRI: convolutional neural network versus vision transformer.

Background And Purpose: White matter hyperintensities in brain MRI are key indicators of various neurological conditions, and their accurate segmentation is essential for assessing disease progression. This study aims to evaluate the performance of a 3D convolutional neural network and a 3D Transformer-based model for white matter hyperintensities segmentation, focusing on their efficacy with limited datasets and similar computational resources.

Materials And Methods: We implemented a convolution-based model (3D ResNet-50 U-Net with spatial and channel squeeze & excitation) and a Transformer-based model (3D Swin Transformer with a convolutional stem).

Cognitive impairments in chronic pain: a brain aging framework.

Chronic pain (CP) not only causes physical discomfort but also significantly affects cognition. This review first summarizes emerging findings that reveal complex associations between CP and cognitive impairments, and then presents neuroimaging evidence showing aging-related brain alterations in CP and proposes a framework where accelerated brain aging links CP to cognitive impairments. This framework explains how CP-related multi-level factors, which either contribute to the onset of CP or arise as a result of CP, influence brain aging in linear and nonlinear ways, leading to cognitive impairments and increased dementia risk.

Alanine supplementation enhancing cordycepin production in Cordyceps militaris via upregulation of Cns2 and Cns3 genes expression levels.

Cordycepin, a key bioactive compound produced by Cordyceps militaris, faces the challenge of low productivity for commercial use. In this study, alanine supplementation in Cordyceps militaris boosted cordycepin production, peaking at 3 mg/g with 12 g/L concentration. Transcriptome analysis revealed 1711 differentially expressed genes, Pathway analysis indicates that protein processing in the endoplasmic reticulum was the most affected pathway.