Mice deficient in TWIK-1 are more susceptible to kainic acid-induced seizures.

TWIK-1 belongs to the two-pore domain K (K2P) channel family, which plays an essential role in the background K conductance of cells. Despite the development of exon 2-deleted knockout (KO) mice, the physiological role of TWIK-1 has remained largely unknown. Here, we observed that the exon 2-deleted KO mice expressed an internally deleted TWIK-1 (TWIK-1 ΔEx2) protein, which unexpectedly acts as a functional K channel.

The Construction of a Stream Service Application with DeepStream and Simple Realtime Server Using Containerization for Edge Computing.

This paper addresses the increasing demand for efficient and scalable streaming service applications within the context of edge computing, utilizing NVIDIA Jetson Xavier NX hardware and Docker. The study evaluates the performance of DeepStream and Simple Realtime Server, demonstrating that containerized applications can achieve performance levels comparable to traditional physical machines. The results indicate that WebRTC provides superior low-latency capabilities, achieving delays of around 5 s, while HLS typically experiences delays exceeding 10 s.

Head-to-Head Comparison of Aptamer- and Antibody-Based Proteomic Platforms in Human Cerebrospinal Fluid Samples from a Real-World Memory Clinic Cohort.

High-throughput proteomic platforms are crucial to identify novel Alzheimer's disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan 7k) and antibody-based (Olink Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan assays analyzing the same samples, and between SomaScan and Olink results.

Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.

The hair follicle is a complex of mesenchymal and epithelial cells acquiring different properties and characteristics responsible for fulfilling its inductive and regenerative role. The epidermal and dermal crosstalk induces morphogenesis and maintains hair follicle cycling properties. The hair follicle is enriched with pluripotent stem cells, where dermal papilla (DP) cells and dermal sheath (DS) cells constitute the dermal compartment and the epithelial stem cells existing in the bulge region exert their regenerative role by mediating the epithelial-mesenchymal interaction (EMI).

Effects of abdominal muscle strengthening and pelvic control exercises on trunk control and pelvic movement in children with unilateral cerebral palsy.

Children with unilateral cerebral palsy (CP) exhibit abnormal movements due to atypical pelvic movements and weakness of trunk muscles. We investigated the effects of abdominal muscle strengthening and pelvic control exercises on trunk control, abdominal muscle thickness change rate, and pelvic movement in children with unilateral CP. Fourteen children with unilateral CP were randomly divided into two groups, and abdominal muscle strengthening and pelvic control exercises were applied to the experimental group, and general physical therapy was applied to the control group, 30 min per session, twice a week, for a total of 8 weeks, respectively.