Measurements of tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots of people receiving pre-exposure prophylaxis for HIV with co-formulated tenofovir disoproxil fumarate and emtricitabine.

Background/purpose(s): Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in the Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) (TDF/FTC) are limited, and the associations between the frequency of TDF/FTC administration and drug concentration among people receiving on-demand PrEP remain unclear.

Methods: Fifty-seven participants receiving daily TDF/FTC and 113 participants receiving on-demand TDF/FTC were enrolled in this study. The concentrations of TFV-DP and FTC-TP were measured in dried blood spots using liquid chromatography‒mass spectrometry.

Dual-energy CT angiography-Guided vascularised free thoracodorsal artery lateral branch chimeric flaps for complex maxillofacial defect repair: An anatomical and clinical study.

A modified thoracodorsal artery lateral branch (TDAL) chimeric flap was developed using dual-energy computed tomography (CT) angiography data of perforators to explore the anatomical characteristics and postoperative outcomes of TDAL flaps in complex maxillofacial defect repair. TDAL flaps were harvested from patients with locally advanced oral cancer. Preoperative perforator detection was performed with dual-energy CT angiography.

Probiotic-fermented ginger-processed Gastrodia elata BI. Ameliorates AlCl-induced cognitive dysfunction in an Alzheimer's disease rat model by regulating the gut microbiota and CREB/BDNF pathway.

Gastrodia elata BI., which is an edible plant, has been reported in previous studies to possess a strong capacity for alleviating the symptoms of Alzheimer's disease (AD). This study focuses on ginger-processed and fermented Gastrodia elata BI.

Longitudinal, Bidirectional Association Between Gait Speed and Cognitive Function in Community-Dwelling non-demented Older Adults.

Objectives: The causal relationship between slow gait speed and poor cognition is uncertain due to potential reverse causality. This study aimed to examine the reciprocal relationship between gait speed and global as well as domain-specific cognitive functions in older adults.

Design: Prospective cohort study (2013-2022) including 4 repeated measures.

Potential of submerged macrophytes restoration for reducing CH and CO emissions in a typical urban lake.

As one of the areas most affected by human activities, urban lakes play a crucial role in global carbon cycle. Currently, submerged macrophyte restoration is a common ecological practice in urban lakes, primarily aimed at improving water quality and enhancing the aesthetic value of lake environments. Despite its widespread application, its contribution to carbon emission reduction has not received sufficient attention.