Publications by authors named "Y Y Shebunyaeva"
Hodgkin's lymphomas (HL) and the majority of non-Hodgkin's lymphomas (NHL) derive from different stages of B-cell differentiation. MicroRNA (miRNA) expression profiles change during lymphopoiesis. Thus, miRNA expression analysis can be used as a reliable diagnostic tool to differentiate tumors.
View Article and Find Full Text PDFBackground: Hodgkin's lymphoma (HL) is one of the most common malignant lymphoproliferative diseases. Chemotherapy and radiotherapy used in the treatment of LH induce a number of toxic effects leading to dysfunction of endocrine system. Hormonal disorders in HL and their relationships with the therapy used remain to be clarified.
View Article and Find Full Text PDFArticle Synopsis
- Non-Hodgkin lymphoma (NHL) is a diverse group of cancers with varying causes and outcomes, primarily treated through chemotherapy, immunochemotherapy, and radiation, but many cases resist these treatments or relapse quickly.
- Aberrant microRNA (miRNA) expression plays a significant role in the development and progression of malignant lymphoid tumors, prompting a study comparing the miRNA profiles in patients with diffuse large B-cell lymphoma (DLBCL) against those with reactive lymphadenopathy (RL).
- The research found that miR-150 levels were significantly lower in DLBCL patients, indicating its potential as a therapeutic target, especially since it is involved in regulating blood cell formation.