Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach.

This study assesses the utility of early biomarkers-5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)-for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital heart defects (CHD). Due to the risks associated with invasive diagnostics, such as right heart catheterization, non-invasive biomarkers provide a safer alternative for early PH detection. This cohort-based study utilized blood and urine samples to measure 5-HIAA and IGF-1 levels via enzyme immunoassays.

[THE SYSTEM OF SEROTONIN AND ITS METABOLISM IN PLATELETS IN CHILDREN WITH CONGENITAL HEART DEFECTS OF AN EARLY AGE].

The main initiator of the development of PAH is the development of endothelial dysfunction of the pulmonary vessels. The cause of this dysfunction is associated with functional disorders of the serotonin system. This research is devoted to study the role of the serotonin system in the development mechanism of PAH in children with CHD.

THE INFLUENCE OF THE PHYSICAL ACTIVITY OF A MODERN STUDENT ON THE CHARACTERISTICS OF THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS AND THEIR RESISTANCE TO STRESS DURING EDUCATIONAL PROCESS.

Many students in the educational process are subject to emotional, cognitive, motivational stress. A little physical activity allows them to get out of this state. One aspect of the research of adaptation of the students to the educational and physical loads is the investigation of their cardiovascular and respiratory systems state.

[On mechanism of functional changes in the organism of teenagers at different levels of locomotor activity].

Comprehensive study of the cardiovascular system functional condition of 15-16 teenagers while in normal daily locomotor activity and in the mode of regular moderate physical activity was performed. The features of cerebral circulation and myocardium functional condition of teenagers are studied depending on initial tonus of the autonomic nervous system and locomotor activity level in the process of continuous step physical activity on tredmil. The condition of regulatory mechanisms, providing adaptation of teenagers in the conditions of modern school was studied.