Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment.

Cell therapy is an emerging strategy for precision treatment of scleroderma. This review systematically summarizes the research progress of mesenchymal stem cell (MSC) and chimeric antigen receptor T cell (CAR-T) therapies in scleroderma and discusses the challenges and future directions for development. MSCs possess multiple functions, including immunomodulation, anti-fibrosis, and promotion of vascular regeneration, all of which can improve multiple pathological processes associated with scleroderma.

Antibiotic duration for common bacterial infections-a systematic review.

Background: Reducing antibiotic duration is a key stewardship intervention to mitigate antimicrobial resistance (AMR). We examined current evidence informing antibiotic duration for common bacterial infections to identify any gaps in terms of settings, patient populations and infectious conditions. Trial methodologies were assessed to identify areas for improvement.

Thyroxine alleviates interstitial lung disease induced by combined radiotherapy and immunotherapy.

Immune checkpoint blockade (ICB) combined with radiotherapy (RT) has improved patients survival, but also increased the risk of pulmonary adverse effects (AEs). Therefore, to explore potential drug targets for interstitial lung disease (ILD), we investigated the interaction of ICB and RT in pulmonary AEs using the disproportionality analysis and COX regression. Genome-wide association studies, transcriptome analysis, and vivo models highlighted the role of programmed death-ligand-1 (PD-L1) in ILD.

Potential of lavender essential oil to inhibit tetracycline resistance and modulate gut microbiota in black soldier fly larvae.

The misuse of tetracycline in livestock farming leads to environmental residues that promote the proliferation of antibiotic resistance genes (ARGs), particularly tetracycline resistance (tet) genes. Black soldier fly (BSF) larvae, used for organic waste bioconversion, may carry tetracycline residues in their guts, raising concerns about ARG spread. To address this issue, plant-derived additives such as lavender essential oil (LEO) have been explored as alternative antibiotics.

Genetic Mediators of Celiac Disease and Premature Ovarian Failure: Hypothyroidism and Systemic Lupus Erythematosus.

Background: Observational studies suggested celiac disease (CD) possibly be a risk factor for premature ovarian failure (POF). However, causality remains unclear. And hypothyroidism and systemic lupus erythematosus may be the mediating factors.