Publications by authors named "Y Y Kwan"
Background: Sclerostin (SOST) is traditionally regarded as an osteocyte-derived secreted glycoprotein that regulates bone mineralization. Recent studies reported that SOST is also released from non-skeletal sources, especially during inflammation. However, the cellular source and regulatory mechanisms governing SOST generation in inflammation remain unclear.
View Article and Find Full Text PDFObjective: The escalating prevalence of Type 2 Diabetes Mellitus (T2DM) overwhelms healthcare systems. Lifestyle interventions enhancing patient monitoring and adherence vary in efficacy, emphasizing the need to understand differential response across patient subgroups. This study aimed to segment patients with T2DM into distinct latent classes and identify characteristics associated with optimal 12-month glycated haemoglobin (HbA1c) reduction.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how using small datasets to select an optimal cutoff score for the Patient Health Questionnaire-9 (PHQ-9) can lead to inaccurate results.
- Researchers evaluated whether data-driven methods for cutoff selection resulted in scores that were significantly different from the true population optimal score and if these methods produced biased accuracy estimates.
- Findings showed that many small studies frequently failed to identify the correct optimal cutoff score, particularly in smaller samples, leading to an overestimation of test sensitivity.
Article Synopsis
- Advanced care planning (ACP) involves ongoing discussions among patients, families, and healthcare professionals about future healthcare needs.
- Patients with rheumatic diseases often face significant symptoms and complications, but the rate of completed ACP in this group is low.
- A quality improvement project in Singapore successfully increased ACP completion rates from 0 to 1 per month over a year through two Plan-Do-Study-Act cycles, indicating a need for further research on enhancing ACP engagement in these patients.
Feasibility, reliability and validity of self-measurement of knee range-of-motion using an accelerometer-based smartphone application by patients with total knee arthroplasty.
PLoS One
October 2024
Article Synopsis
- After knee surgery, many people struggle to move their knees properly, which can make them unhappy and limit their activities.
- This study looked at whether patients could accurately measure their knee movement using a special app on their smartphones instead of needing a healthcare professional.
- The results showed that almost all patients could use the app easily, and it gave very reliable measurements of knee movement.