Inhibition of the Integrated Stress Response Prevents Natural Forgetting and Corrects Accelerated Forgetting Associated with Epilepsy.

The neural mechanisms underlying the natural and maladaptive forgetting of established memory remain largely unknown. Brain disease states might hijack the physiological forgetting mechanisms, resulting in maladaptive forgetting such as accelerated forgetting that contributes to cognitive decline in various neurologic conditions including epilepsy. Based on the key role of the integrated stress response (ISR) in memory storage and maintenance, we determined whether the ISR underpins natural and accelerated forgetting.

Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates both oxidative stress and mitochondrial biogenesis. Our previous study reported the cardioprotection of calycosin against triptolide toxicity through promoting mitochondrial biogenesis by activating nuclear respiratory factor 1 (NRF1), a coregulatory effect contributed by Nrf2 was not fully elucidated. This work aimed at investigating the involvement of Nrf2 in mitochondrial protection and elucidating Nrf2/NRF1 signaling crosstalk on amplifying the detoxification of calycosin.

Macrophages in inflammatory skin diseases and skin tumors.

Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma.

Expandable Fast Li-Ion Diffusion Network of Li-Rich Mn-Based Oxides via Single-Layer LiCo(Ni)O Segregation.

Li-rich Mn-based cathode materials exhibit a remarkable reversible specific capacity exceeding 250 mAh g, positioning them as the preferred choice for the next generation of high-energy density lithium-ion battery cathode materials. However, their inferior rate and cycling performance pose significant challenges. In this context, a Li-rich material incorporating an expanded fast Li-ion diffusion network has been successfully synthesized.

The relationships between short video addiction, subjective well-being, social support, personality, and core self-evaluation: a latent profile analysis.

Background: The proportion of short video addiction (SVA) is increasing among different populations, and its impact on the adolescent group has attracted research attention in recent years. To better explore the heterogeneity of individuals addicted to short videos and the antecedents of their addiction, the present study used quantitative research to conduct a latent profile analysis (LPA) of college students' SVA from the perspective of internal and external resources.

Methods: Referring to the Interaction of Person-Affect-Cognition-Execution (I-PACE) theory, this study explores the relationship between subgroups of SVA on the one hand and subjective well-being (SWB), social support (SS), core self-evaluation (CSE), and extraversion on the other using latent profile analysis.