The role of inflammatory gene polymorphisms in severe COVID-19: a review.

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate interplay between the virus and the host immune response, particularly the role of inflammatory gene expression in severe COVID-19. While numerous previous studies have explored the role of genetic polymorphisms in COVID-19, research specifically focusing on inflammatory genes and their associations with disease severity remains limited.

Langendorff Isolated Heart Perfusion Model for Functional Studies in Mice.

The ex vivo isolated heart perfusion model by Oskar Langendorff to resuscitate and maintain the automacity of a heart excised from a mammal was introduced in the late nineteenth century. It has remained an essential technique used for functional studies in cardiovascular research even after over a hundred years. This model provides information on contractility, cardiac rhythm, metabolism, and overall cardiac function.

Decreasing Agitation in Neurodiverse Patients with Mental Health Concerns.

Purpose: Children and adolescents are experiencing a mental health crisis. Neurodiverse patients have high rates of mental health conditions and worse outcomes. To address this disparity, the Autism Spectrum Disorder Care Pathway was applied to a pediatric emergency department (PED) and Observation Unit (OU) in order to decrease agitation experienced by these patients.

Healthcare utilisation patterns and contributory factors among middle-aged adults: a scoping review.

Background: Middle-aged adults, defined as individuals between the ages of 45 and 64, represent a significant yet under researched group of healthcare service users. This scoping review aimed to provide a comprehensive overview of the patterns of healthcare utilisation and the factors contributing to them within this demographic.

Methods: Following PRISMA-ScR guidelines and the framework proposed by Arksey and O'Malley, a systematic literature search was conducted across PubMed, EMBASE, and the Cochrane Library databases from their inception until July 2023.