Publications by authors named "Y Wedatilake"
Female Reproductive Factors and Risk of Mild Cognitive Impairment and Dementia: The HUNT Study.
J Prev Alzheimers Dis
July 2024
Article Synopsis
- Women are more likely than men to experience dementia, and this study investigates potential links between menopausal and menarcheal ages to the risk of mild cognitive impairment (MCI) and dementia.
- Over a long-term study in Norway involving over 5,000 women aged 70 and older, menopause age was inversely associated with dementia risk, with earlier menopause linked to a significantly higher risk.
- No significant connections were found between menarche age and dementia or MCI, suggesting that menopause timing may be a crucial factor in understanding cognitive decline in women.
Article Synopsis
- - The study investigates the genetic factors behind neuropsychiatric symptoms common in Alzheimer's disease, specifically psychosis (AD+P) and affective disturbances like depression and anxiety (AD+A).
- - Using a large sample of nearly 10,000 Alzheimer's participants, researchers found genetic correlations between AD+P and AD+A, but these two conditions also showed distinct genetic profiles when compared to psychiatric disorders in non-AD individuals.
- - The findings highlight the need for integrating genetic data to develop better treatments, as both psychosis and affective symptoms in Alzheimer's have shared and differing genetic associations.
High blood pressure is a well-established risk factor of dementia. However, the timing of the risk remains controversial. The aim of the present study was to compare trajectories of systolic blood pressure (SBP) over a 35-year follow-up period in the Health Survey in Trøndelag (HUNT) from study wave 1 to 4 in people with and without a dementia diagnosis at wave 4 (HUNT4).
View Article and Find Full Text PDFX-linked hypophosphatemia (XLH) is the most common monogenic disorder causing hypophosphatemia. This case-note review documents the clinical features and the complications of treatment in 59 adults (19 male, 40 female) with XLH. XLH is associated with a large number of private mutations; 37 different mutations in the PHEX gene were identified in this cohort, 14 of which have not been previously reported.
View Article and Find Full Text PDFObjective: 3-Methylglutaconic aciduria, dystonia-deafness, hepatopathy, encephalopathy, Leigh-like syndrome (MEGDHEL) syndrome is caused by biallelic variants in SERAC1.
Methods: This multicenter study addressed the course of disease for each organ system. Metabolic, neuroradiological, and genetic findings are reported.