Publications by authors named "Y W Sia"
Article Synopsis
- The study investigates how often to screen critically ill adults on ventilators and the best method for conducting spontaneous breathing trials (SBT) to successfully extubate them.
- It involves a randomized clinical trial with 797 participants who required mechanical ventilation, comparing once-daily and more frequent screenings alongside two SBT techniques: pressure-supported and T-piece.
- Results show no significant differences in the time to successful extubation based on screening frequency or SBT technique, indicating that both methods may be similarly effective.
Renal interstitial fibrosis is an important mechanism in the progression of chronic kidney disease (CKD) to end-stage kidney disease. However, we lack specific treatments to slow or halt renal fibrosis. Ribosome profiling identified upregulation of a secreted micropeptide, C4orf48 (Cf48), in mouse diabetic nephropathy.
View Article and Find Full Text PDFNucleosomes are basic repeating units of chromatin and form regularly spaced arrays in cells. Chromatin remodelers alter the positions of nucleosomes and are vital in regulating chromatin organization and gene expression. Here we report the cryo-EM structure of chromatin remodeler ISW1a complex from Saccharomyces cerevisiae bound to the dinucleosome.
View Article and Find Full Text PDFArticle Synopsis
- The FAST-NAWC trial is a multicenter study that aims to compare different screening frequencies and techniques for spontaneous breathing trials in critically ill patients on ventilation in 20 North American ICUs.
- The original protocols have been updated to include COVID-19 patients, and changes were made to the statistical analysis plan to accommodate data reporting for both COVID-19 and non-COVID-19 participants.
- The trial has been registered on Clinical Trials.gov, and this update outlines the key protocol modifications and their purpose before the final follow-up and data analysis phases.
Introduction: Moderate intensity continuous training (MICT) is usually recommended for stroke or transient ischemic attack (TIA) patients. High intensity interval training (HIIT) has emerged as a potentially effective method for increasing cardiorespiratory fitness (CRF) among clinical populations. Its effectiveness remains to be demonstrated after stroke.
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