Glimepiride/hydroxypropyl-β-cyclodextrin inclusion compound: preparation, characterization, and evaluation.

Objective: To enhance solubility and bioavailability of glimepiride (GM), an inclusion compound of glimepiride/hydroxypropyl-β-cyclodextrin (GM/HP-β-CD) was prepared using mechanical ball milling.

Significance: Based on response surface optimization for the ball milling preparation of the inclusion compound, this study investigates it in vitro and in vivo release and pharmacokinetics.

Methods: GM/HP-β-CD inclusion compound was prepared by optimized ball milling based on response surface methodology and characterized using powder x-ray diffraction, differential scanning calorimetry, scanning electron microscopy and fourier transform infrared spectroscopy, and the stability of the compound were studied.

Molecular Mechanism of Aerobic Exercise Ameliorating Myocardial Mitochondrial Injury in Mice with Heart Failure.

To explore the molecular mechanism of aerobic exercise to improve heart failure and to provide a theoretical basis and experimental reference for the treatment of heart failure. Nine-week-old male mice were used to establish a left ventricular pressure overload-induced heart failure model by transverse aortic constriction (TAC). The mice were randomly divided into four groups: a sham group (SHAM), heart failure group (HF), heart failure + SKQ1 group (HS) and heart failure + aerobic exercise group (HE).

Comparative Genomic Analysis of the Poaceae Cytokinin Response Regulator Gene Family and Functional Characterization of in Drought Stress Tolerance in Rice.

The cytokinin (CK) type B response regulator () gene is involved in the CK signaling pathway and performs a key function for mediating reactions to amounts of abiotic stresses. Nevertheless, the gene family remains to be characterized in Poaceae (also known as Gramineae or grasses). Here, we performed a comprehensive analysis encompassing phylogenetic relationships, evolutionary pressures, and expression patterns of the gene family in six Poaceae species, including rice, , , , maize, and wheat.

FeMo integrated covalent organic frameworks: Peroxidase-mimetic colorimetric biosensors for multivariate sensing hydrogen peroxide and ascorbic acid in serum and beverages.

An efficient and readable sensor is desirable for food safety and diagnosis. Herein, a homogeneous mimicking enzyme was constructed by encapsulating polyoxometalate (NH₄)₃[FeMo₆O₁₈(OH)₆]·6H₂O (FeMo) into the covalent organic framework (FeMo@COF). Coordinating the spatial confinement effect of COF, FeMo exhibited superior peroxide-like activity to catalyze HO to O• which achieved the "on-off" consecutive sensing of HO and AA via a readable colorimetric mode, with the limit of detection (LOD) at 30 μM and 0.

Preparation of Thermally Conductive and Flame Retardant Epoxy Composites from Polyethylenimine-Boron Nitride Skeleton and Phosphate Ester Hyperbranched Flame Retardant.

In the electronics field, the demand for polymer-based interface materials with high thermal conductivity is increasing. In this study, a three-dimensional thermally conductive framework was fabricated using a bidirectional freezing technique, incorporating hexagonal boron nitride (h-BN) as the primary filler and polyethylenimine (PEI) as the binder. Moreover, a phosphate ester hyperbranched flame retardant (DTFR) was synthesized.