Mechanisms of Autophagy in Ineffective Reperfusion After Ischemic Stroke.

Despite significant advancements in achieving high recanalization rates (80%-90%) for large vessel occlusions through mechanical thrombectomy, the issue of "futile recanalization" remains a major clinical challenge. Futile recanalization occurs when over half of patients fail to experience expected symptom improvement after vessel recanalization, often resulting in severe functional impairment or death. Traditionally, this phenomenon has been attributed to inadequate blood flow and reperfusion injury.

Deciphering dengue: novel RNA barcoding segments for enhanced serotype-specific identification and global surveillance of dengue viruses.

Introduction: Dengue viruses (DENVs), the causative agents of dengue hemorrhagic fever and dengue shock syndrome, undergo genetic mutations that result in new strains and lead to ongoing global re-infections.

Objectives: To address the growing complexity of identifying and tracking biological samples, this study screened RNA barcode segments for the four DENV serotypes, ensuring high specificity and recall rates for DENV identification using segments.

Results: Through analyzing complete genome sequences of DENVs, we screened eight barcode segments for DENV, DENV-1, DENV-2, DENV-3, and DENV-4 identification.

A Comparison of Short-Term Peripheral Nerve Stimulation and Pulsed Radiofrequency in the Treatment of Postherpetic Neuralgia.

Objective: To compare the application effects of short-term peripheral nerve stimulation (st-PNS) and pulsed radiofrequency (PRF) technology in postherpetic neuralgia (PHN).

Methods: A retrospective analysis was conducted on the clinical data of 127 PHN patients from our hospital. Based on the treatment interventions received, patients were divided into a control group (n=63, treated with PRF) and an observation group (n=64, treated with st-PNS).

A Wireless Health Monitoring System Accomplishing Bimodal Decoupling Based on an "IS"-Shaped Multifunctional Conductive Hydrogel.

Flexible wearable sensors with bimodal functionality offer substantial value for human health monitoring, as relying on a single indicator is insufficient for capturing comprehensive physiological information. However, bimodal sensors face multiple challenges in practical applications, including mutual interference between various modalities, and integration of excellent mechanical properties, interfacial adhesion, environmental adaptability and biocompatibility. Herein, the multifunctional hydrogel, synthesized through radical grafting and supramolecular self-crosslinking reactions, exhibits excellent thermal sensitivity (TCR = -1.

Habitat-based MRI radiomics to predict the origin of brain metastasis.

Background: This study aims to explore the value of habitat-based magnetic resonance imaging (MRI) radiomics for predicting the origin of brain metastasis (BM).

Purpose: To investigate whether habitat-based radiomics can identify the metastatic tumor type of BM and whether an imaging-based model that integrates the volume of peritumoral edema (VPE) can enhance predictive performance.

Methods: A primary cohort was developed with 384 patients from two centers, which comprises 734 BM lesions.