BIOCHEMICAL AND MORPHOLOGICAL MARKERS OF EXPERIMENTAL SCOPOLAMINE-INDUCED NEURODEGENERATION AND THE EFFECT OF ENALAPRIL ON THEM.

Objective: The aim: Was to study enalapril effect on protein peroxide oxidation and lipids of the cerebral cortex and hippocampus of rats with neurodegeneration pattern.

Patients And Methods: Materials and methods: The experiments were conducted on nonlinear albino male rats 0,18-0,20 kg of the body weight. Modeled neurodegeneration was simulated by intraperitoneal introduction of scopolamine hydrochloride during 27 days in the dose of 1 mg/kg.

EFFECT OF MELATONIN INJECTIONS ON THE GLUTATHIONE SYSTEM IN HEART TISSUE OF RATS UNDER EXPERIMENTAL DIABETES.

The aim was to determine the influence of melatonin on basal levels of glucose (BG), the level of thiobarbituric acid reactive compounds (TBCRC), reduced glutathione (GSH) levels, activities of glutathione reductase (GR), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G-6-PhD) in the heart tissue of alloxan diabetic rats. Alloxan diabetes was evoked via intraperitoneal injection with a 5% solution of alloxan monohydrate in a dose of 170 mg/kg of body weight. There were 5 groups: 1) control group (n=8); 2) group with DM (BG level ≥ 8.

ENALAPRIL EFFECT ON GLUTATHIONE CHAIN OF THE ANTIOXIDANT SYSTEM OF THE BRAIN IN RATS WITH SCOPOLAMINE-INDUCED NEURODEGENERATION.

Objective of the work is to study enalapril effect, a blocker of renin-angiotensin system, on glutathione chain of the antioxidant system of the cerebral cortex and hippocampus of rats with experimental neurodegeneration. The experiments were conducted on nonlinear laboratory albino male rats with their body weight of 0,18-0,20 kg. The model of neurodegeneration was created by means of intraperitoneally administration of scopolamine hydrochloride (Sigma, USA) during 27 days in the dose of 1 mg/kg.