Azepine-Indole Alkaloids From Modulate 5-HT Receptors and Prevent Protein Toxicity in Transgenic .

Nemorosine A () and fargesine (), the main azepine-indole alkaloids of , were explored for their pharmacological profile on neurodegenerative disorders (NDs) applying a combined -- approach. By using and as queries for similarity-based searches of the ChEMBL database, structurally related compounds were identified to modulate the 5-HT receptor; experiments confirmed an agonistic effect for and (24 and 36% at 10 μM, respectively), which might be linked to cognition-enhancing properties. This and the previously reported target profile of and , which also includes BuChE and MAO-A inhibition, prompted the evaluation of these compounds in several models linked to 5-HT modulation and proteotoxicity.

Secondary-metabolites fingerprinting of Argania spinosa kernels using liquid chromatography-mass spectrometry and chemometrics, for metabolite identification and quantification as well as for geographic classification.

Argan (Argania spinosa L.) fruit kernels' composition has been poorly studied and received less research intensity than the resulting Argan oil. The Moroccan Argan kernels contain a wealth of metabolites and can be investigated for nutritional and health aspects as well as for economic benefits.

Modelling approaches for chiral chromatography on polysaccharide-based and macrocyclic antibiotic chiral selectors: A review.

An overview of molecular modelling approaches, related to chiral separations on polysaccharide-based and macrocyclic antibiotic chiral selectors, is presented. Both atomistic calculations and empirical fitting procedures are discussed. Atomistic calculations, such as docking and molecular dynamics can be used to model the interactions between enantiomers and the chiral stationary phase.

Quality Control of Herbal Medicines: From Traditional Techniques to State-of-the-art Approaches.

Herbal medicines are important options for the treatment of several illnesses. Although their therapeutic applicability has been demonstrated throughout history, several concerns about their safety and efficacy are raised regularly. Quality control of articles of botanical origin, including plant materials, plant extracts, and herbal medicines, remains a challenge.

UPLC-PDA-ESI-QTOF-MS/MS and GC-MS analysis of Iranian L.

L. is a significant component in the Iranian food basket. This study aimed to investigate the bioactive compounds and biological activities of different extracts obtained from aerial parts.