Publications by authors named "Y V Shchukin"
Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem and explore the fundamental and functional properties of CPP rotaxanes and catenanes, researches have resorted to unusual non-covalent and even to labor-intensive covalent template approaches. Herein, we report a ring-in-ring non-covalent template strategy that makes use of the surprisingly strong non-covalent inclusion of crown ethers into suitably sized CPPs.
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- The study focused on developing an effective model to predict arterial vascular complications in patients with extrasystolic arrhythmia, specifically those with 700 or more extra beats per day.
- It involved 634 patients and a control group of 106 individuals, utilizing various laboratory and imaging tests over a year to track complications like strokes and heart attacks.
- The Bootstrap Forest model emerged as the best performing model, leading to the creation of a predictive score for arterial complications in these patients.
Article Synopsis
- The study aimed to analyze clinical data from patients with non-obstructive ischemic heart disease (IHD) and multifocal atherosclerosis (MFA) in the KAMMA registry, focusing on those who underwent coronary angiography (CAG).
- Out of 1,893 IHD patients, only 8.7% had non-obstructive coronary atherosclerosis (CA), with many affected by MFA in various arteries, especially the brachiocephalic and lower extremity arteries.
- Patients with non-obstructive CA, predominantly women, had fewer traditional risk factors like smoking and diabetes, but higher cholesterol levels; they also experienced less severe IHD and acute coronary syndrome compared to those with obstructive
A prospective study of 92 patients over 70 years old with myocardial infarction was carried out. All patients were diagnosed and determined the severity of geriatric syndromes, including fragility, using specialized scales on the 5th day of hospitalization. The comorbidity was assessed with the calculation of the Charlson Comorbidity Index, levels of NT-proBNP, ST-2, FGF-21, VEGF in blood serum by enzyme immunoassay.
View Article and Find Full Text PDFDynamic covalent chemistry has become an invaluable tool for the design and preparation of adaptable yet robust molecular systems. Herein we explore the scope of a largely overlooked dynamic covalent reaction - amidinium exchange - and report on conditions that allow formal amidinium metathesis reactions.
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