Evaluation of Vinca Rosea's Protective Effects on Hepatic Function in Streptozotocin-Induced Diabetic Wistar Albino Rats.

Background Diabetes mellitus, characterized by chronic hyperglycemia, often leads to severe hepatic dysfunction, including increased liver enzyme levels and histopathological changes in the liver. Streptozotocin (STZ)-induced diabetic rat models provide a valuable method for evaluating potential therapeutic agents that target hepatic complications. , a medicinal plant with known anti-diabetic properties, has been used traditionally for its hepatoprotective effects, although scientific evidence is limited.

Antiarthritic potential of ethanolic extract of Ixora coccinea leaves on complete Freund's adjuvant-induced arthritis in animal model.

Context: Ixora coccinea leaves possess antioxidant, anti-inflammatory, antinociceptive, antimutagenic, and gastroprotective properties. On this background, its antiarthritic potential was evaluated.

Aims: The objective is to evaluate the effect of Ethanolic extract of Ixora coccinea leaves (EEICL) on complete Freund's adjuvant-induced arthritis in rats.

The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking.

Epithelial-mesenchymal transition (EMT) plays important roles in tumour progression and is orchestrated by dynamic changes in gene expression. While it is well established that post-transcriptional regulation plays a significant role in EMT, the extent of alternative polyadenylation (APA) during EMT has not yet been explored. Using 3' end anchored RNA sequencing, we mapped the alternative polyadenylation (APA) landscape following Transforming Growth Factor (TGF)-β-mediated induction of EMT in human mammary epithelial cells and found APA generally causes 3'UTR lengthening during this cell state transition.

Quaking isoforms cooperate to promote the mesenchymal phenotype.

The RNA-binding protein Quaking (QKI) has widespread effects on mRNA regulation including alternative splicing, stability, translation, and localization of target mRNAs. Recently, QKI was found to be induced during epithelial-mesenchymal transition (EMT), where it promotes a mesenchymal alternative splicing signature that contributes to the mesenchymal phenotype. QKI is itself alternatively spliced to produce three major isoforms, QKI-5, QKI-6, and QKI-7.

Corrigendum to "Nephroprotective Effect of Herbal Extract on Paracetamol-Induced Nephrotoxicity in Rats".

[This corrects the article DOI: 10.1155/2019/4916519.].