Publications by authors named "Y V Ostankova"
Human immunodeficiency virus (HIV) continues to be a global health challenge, with over 38 million people infected by the end of 2022. HIV-1, the predominant strain, primarily targets and depletes CD4+ T cells, leading to immunodeficiency and subsequent vulnerability to opportunistic infections. Despite the progress made in antiretroviral therapy (ART), drug resistance and treatment-related toxicity necessitate novel therapeutic strategies.
View Article and Find Full Text PDFAccording to recent data, there are currently 170 to 200 million people infected with HCV worldwide, and the number of new cases annually is approximately 40,000. Thus, the overall prevalence of the pathogen in the world is about 1.8-3%.
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- * A study assessed HIV mutation prevalence in children under 18 months who tested positive, finding 3.43% positivity rate in blood samples, with 62.9% showing drug resistance mutations, particularly against NNRTIs.
- * The study revealed that children receiving PMTCT had higher rates of resistance mutations compared to those who didn’t, with late HIV testing access being an issue for both infected mothers and children.
According to the latest data released by UNAIDS, the global number of people living with HIV (PLHIV) in 2021 was 38.4 million, with 1.5 million new HIV infections.
View Article and Find Full Text PDFUnlabelled: The aim of the work is to assess the prevalence of hepatitis B virus drug resistance mutations and immune escape mutations in pregnant women in the Republic of Guinea.
Materials And Methods: Blood plasma samples obtained from 480 pregnant women from different regions of the Republic of Guinea with laboratory-confirmed viral hepatitis B were studied. Nucleotide sequences for genotype identification and mutation detection were obtained using nested-PCR followed by Sanger sequencing, based on overlapping pairs of primers spanning the complete genome of the virus.