Publications by authors named "Y V Karakulova"
Article Synopsis
- - The study aimed to assess the impact of Neuromidine on pain relief for patients suffering from discogenic lumbosacral radiculopathy, comparing a treatment group (OG) that received Neuromidine alongside standard therapy to a control group (HS) that only received standard therapy.
- - After 8 weeks, the treatment group showed significantly greater reductions in pain intensity, improved cognitive function, and better emotional health compared to the control group, along with a marked decrease in the inflammatory marker IL-6.
- - Neuromidine was well-tolerated with no reported side effects, indicating its potential effectiveness and safety as an addition to existing treatment modalities for this condition.
[Genetic background of dyslexia and dysgraphy in children].
Zh Nevrol Psikhiatr Im S S Korsakova
June 2023
Article Synopsis
- The review focuses on reading and writing disorders in children, identifying them as part of neurodevelopmental disorders, a shift from the traditional view of "brain damage" to a more nuanced understanding in neuroscience.
- It highlights the role of 21 genes linked to reading and writing skills, suggesting that dyslexia and dysgraphia have different genetic bases influenced by factors like ethnicity and language structure.
- The findings indicate that genetic dysfunctions can lead to abnormal brain development, affecting linguistic processing and comprehension, which can aid in creating models for diagnosis and intervention strategies to enhance educational outcomes and address psychosocial impacts.
Despite the significant shift in global attention away from the pandemic, the problem of a new coronavirus infection remains important in the medical community. Almost 3 years after the start of the COVID-19 pandemic the issues of rehabilitation and management of delayed manifestations and sequelae of the disease are especially important. According to numerous available data, the new coronavirus infection is characterized by multiorgan lesions.
View Article and Find Full Text PDF[Treatment of sleep disturbances associated with chronic non-specific low back pain: results of prospective randomized multicenter open-label clinical trial].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2022
Objective: A comparative study of the effectiveness and safety of novel combination naproxen sodium and diphenhydramine in subjects with low back pain along with transient insomnia.
Material And Methods: It was an open label, randomized, comparative, parallel group and multi-center clinical study. Subjects were randomised into one of three treatment arms: naproxen sodium 440 mg/diphenhydramine 50 mg, naproxen sodium 550 mg, Paracetamol 1000 mg/diphenhydramine 50 mg.
Objective: To assess the quantitative serum levels of tropomyosin receptor kinase receptor B, and to estimate its association with serum concentration of brain-derived neurotrophic factor and obesity in patients with painful and painless forms of diabetic polyneuropathy.
Methods: We examined 70 patients with diabetic polyneuropathy with confirming peripheral nerve dysfunction by electroneuromyography and measuring of serum levels tropomyosin receptor kinase receptor B and brain-derived neurotrophic factor by enzyme immunoassay. Diabetic polyneuropathy was diagnosed using the modified Toronto Consensus (2011) criteria, while neuropathic pain was assessed using an 11-point Numerical Pain Rating Scale.