Systemic treatment of the metastatic renal cell carcinoma: usefulness of the apparent diffusion coefficient of diffusion-weighted MRI in prediction of early therapeutic response.

Accurate prediction of early treatment response to systemic therapy (ST) with tyrosine kinase inhibitors (TKI) in patients with metastatic renal cell carcinoma (mRCC) could help avoid ineffective and expensive treatment with serious side effects. Neither RECIST v.1.

[REPRODUCTIVE HEALTH OF GIRLS-TEENAGERS - AS A MEDICAL-SOCIAL PROBLEM OF KAZAKHSTAN].

The purpose of the study - to evaluate the gynecological and somatic pathology of Almaty teenage girls in order to improve measures to improve the reproductive health of this category of the population. As research materials, statistical data on the prevalence of gynecological pathology among teenage girls in Almaty were used, who sought medical help from the Almaty City Center for Human Reproduction (SCCR) and reporting forms from the Almaty city branch of the Republican Center for Electronic Health in 2013 to 2018. In work were applied: analytical, epidemiological, statistical techniques.

[THE ANALYSIS OF MORTALITY CAUSES IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY IN ALMATY].

The purpose of this study was to analyze the cases of traumatic brain injuries in hospitals of Almaty and the factors that cause traumatic brain injury with fatal outcome. The material for the study were clinical cases of patients with traumatic brain injury (TBI) and deaths according to Almaty for 2012-2015, the total number of patients - 217, of which, in 2012 - 56, in 2013 - 48, in 2014 - 51, 2015 - 62. The criterion for inclusion in the study was the presence of an isolated TBI.

[HLA ALLELES IN KAZAKHSTAN AND IN THE GLOBAL GENOFUND].

The HLA alleles in the Kazakhstan genofund and in the global genofund were compared. The study was carried out on 2283 Kazakhstan donors, 4 566 antigens by five locuses A, B, C, DRB1, DQB1. Comparison with the global HLA alleles was carried out using http://www.

[COMPLIANCE OF DOCTORS TO PROTOCOLS IN DIAGNOSTICS AND TREATMENT OF ARTERIAL HYPERTENSION].

Based on the study, data on the compliance of physicians in compliance with national and international protocols for the diagnosis and treatment of hypertension based on the principles of evidence-based medicine were revealed. The obtained data testify to the presence of facts not observing the recommended protocols. In addition, on the basis of the data obtained, insufficient level of joint responsibility was determined, both on the part of patients and on the part of doctors.