A combined school survey and reactive case detection reveals minimal local transmission of malaria in the Highlands Region of Papua New Guinea.

Background: The Highlands of Papua New Guinea are non-endemic for malaria compared to the rest of the country. This study aimed to explore the local transmission of malaria in the Highlands through a cross-sectional school survey coupled with reactive case detection.

Methods: Between July and November 2019, 5575 schoolchildren and 1048 household members were screened for malaria using Rapid Diagnostic Tests, subsequently validated by light microscopy.

Alkyl nitrite-enabled palladium-catalyzed terminal selective oxidative cyclization of 4-penten-1-ols.

Oxidative cyclization of 4-penten-1-ols using a Pd catalyst and -BuONO or -BuONO/-benzoquinone afforded 3-hydroxy- and 3-methoxytetrahydropyrans terminal selective nucleophilic attack. The radicals formed from -BuONO and O operate as critical oxidants and ligands for Pd.

Palladium/Iron-Catalyzed Wacker-Type Oxidation of Aliphatic Terminal and Internal Alkenes Using O.

The Wacker-type oxidation of aliphatic terminal alkenes proceeds using a Pd/Fe catalyst system under mild reaction conditions using 1 atm O without other additives. The use of 1,2-dimethoxyethane/HO as a mixed solvent was effective. The slow addition of alkenes is also important for improving product yields.

Aiming for dynamic behaviours of molecular metal chains.

The dynamical functions of molecular metal chains, that could be derived from unique physical and chemical properties coupled with self-assembly of metal chain components, have largely been unexplored, and this review paper focuses on the dynamic behaviours of Pd chains supported by linear tetraphosphines, - and -PhPCHP(Ph)CHP(Ph)CHPPh recently reported, and the current development on fine-tuning of metal chains by introducing heterometal atoms, heterometallic molecular metal chains, that are considered as promising dynamical components in the next generation.

Synthesis of 2-hydroxytetrahydrofurans by Wacker-type oxidation of 1,1-disubstituted alkenes.

1,1-Disubstituted alkenes feature high steric hindrance, which renders their Wacker-type oxidation difficult. We demonstrate the stereoselective synthesis of 2-hydroxytetrahydrofurans the Wacker-type oxidation of 3-methyl-3-buten-1-ols by using a PdCl(MeCN)/NO/BQ catalyst system under 1 atm O in HO or HO/DMF.