Early rehabilitation with lumbar-type hybrid assistive limb for acute stroke patients: a pilot study and clinical review.

[Purpose] To examine the impacts of using lumbar-type hybrid assistive limbs during the acute stage of stroke, specifically on motor function involving the trunk and activities of daily living, as compared to conventional physical therapy. [Participants and Methods] This was a single-center randomized controlled trial. Participants were randomly assigned to either the hybrid assistive limb or conventional physical therapy groups and underwent early rehabilitation with and without hybrid assistive limb training for ten 40-minute sessions over 10 days.

Efficacy of etanercept biosimilar switching from etanercept reference product, using ultrasound and clinical data in outcomes of real world therapy (ESCORT-NGSK Study).

This study aimed to investigate in detail the efficacy of switching from etanercept reference product (RP) to etanercept biosimilar in patients with rheumatoid arthritis (RA) under real-world clinical conditions using clinical indices and musculoskeletal ultrasound (MSUS). This interventional, multicenter, open-label, single-arm clinical trial involved 24- or 52-week follow-up. This study enrolled patients with RA who had been treated with etanercept-RP for ≥ 24 weeks, achieved clinical low disease activity (LDA) or remission, and switched from etanercept-RP to etanercept biosimilar.

Advances in sporadic brain arteriovenous malformations: Novel genetic insights, innovative animal models, and emerging therapeutic approaches.

Brain arteriovenous malformations (bAVMs) are a notable cause of intracranial hemorrhage, strongly associated with severe morbidity and mortality. Contemporary treatment options include surgery, stereotactic radiosurgery, and endovascular embolization, each of which has limitations. Hence, development of pharmacological interventions is urgently needed.

Differential Risk Factors for Early Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Carcinoma According to the History of Non-Muscle Invasive Bladder Cancer.

Objectives: To evaluate the preoperative risk factors for early intravesical recurrence after radical nephroureterectomy (RNU) in patients with upper urinary tract carcinoma (UTUC) according to the history of non-muscle invasive bladder cancer (NMIBC).

Methods: We retrospectively evaluated patients who underwent RNU for UTUC between 2012 and 2022 at 14 hospitals. Early recurrence was defined as intravesical pathologically confirmed recurrence within 1 year after RNU.