Complete genome sequence of strain JD2-26, a potential pollutant-reducing bacterium isolated from a municipal solid waste landfill facility.

We report here the complete genome sequence of strain JD2-26 isolated from a municipal solid waste landfill facility. The genome consists of a 6.32-Mbp chromosome and a plasmid having a total of 6,100 genes, including 5,914 coding sequences.

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Chemical modification of RNAs is important for posttranscriptional gene regulation. The METTL3-METTL14 complex generates most -methyladenosine (mA) modifications in messenger RNAs (mRNAs), and dysregulated methyltransferase expression has been linked to cancers. Here we show that a changed sequence context for mA can promote oncogenesis.

DenseIncepS115: a novel network-level fusion framework for Alzheimer's disease prediction using MRI images.

One of the most prevalent disorders relating to neurodegenerative conditions and dementia is Alzheimer's disease (AD). In the age group 65 and older, the prevalence of Alzheimer's disease is increasing. Before symptoms showed up, the disease had grown to a severe stage and resulted in an irreversible brain disorder that is not treatable with medication or other therapies.

Advancing Public Health Interventions: A Novel Surveillance System for Hazardous Consumer Products.

Lead poisoning remains a significant public health concern with preventable exposure from different sources, including certain traditional consumer products. To address the concern of product-related lead exposures, the New York City Department of Health and Mental Hygiene has developed the Non-Paint Sample Database (NPSD). NPSD systematically tracks information about hazardous consumer products collected during New York City case investigations and store surveys.

Plasma protein-based and polygenic risk scores serve complementary roles in predicting inflammatory bowel disease.

Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), has a significant genetic component and is increasingly prevalent due to environmental factors. Current polygenic risk scores (PRS) have limited predictive power and cannot inform time of symptom onset. Circulating proteomics profiling offers a novel, non-invasive approach for understanding the inflammatory state of complex diseases, enabling the creation of proteomic risk scores (ProRS).