Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids.

Background: Patient-derived organoids (PDOs) represent a promising approach for replicating the characteristics of original tumors and facilitating drug testing for personalized treatments across diverse cancer types. However, clinical evidence regarding their application to esophageal cancer remains limited. This study aims to evaluate the efficacy of implementing PDOs in clinical practice to benefit patients with esophageal squamous cell carcinoma (ESCC).

Dynamic analysis and optimal control of competitive information dissemination model.

Information dissemination is vital to human production and life. Identifying and analyzing the modes and mechanisms of information dissemination under different conditions is conducive to playing the role of positive information and reducing the impact of negative information. Considering that multiple pieces of information coexist and conflict with each other, in this paper, a competitive information dissemination model is established and the proposed system is analyzed.

Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis.

Fetal growth restriction (FGR) is a common complication of pregnancy, which seriously endangers fetal health and still lacks effective therapeutic targets. Clostridium difficile (C. difficile) is associated with fetal birth weight, and its membrane vesicles (MVs) are pathogenic vectors.

Light People: Prof. Henry Snaith's (FRS) perovskite optoelectronics journey.

In 2012, Prof. Henry Snaith demonstrated the first solid-state perovskite solar cell (PSC) with an efficiency of 10.9%, igniting a surge of interest and research into perovskite materials for their potential to revolutionize the photovoltaic (PV) industry.