Examination of the potential clinical application of 5DEX-0509R, the tumor macrophage-targeting nanomedicine.

Toll-like receptors (TLRs) are crucial for the detection of infections and activation of downstream signaling pathways that lead to the production of pro-inflammatory cytokines and interferons. Because of their strong immunostimulatory activity, TLRs are thought to be a "double-edged sword" for systemic treatment, even in the cancer field. To solve this, we have developed dextran-based TAM targeting activator conjugate (D-TAC) technology which successfully uses tumor-associated macrophages (TAMs) to deliver the TLR7 agonist DSP-0509.

Vegetation at the former open-pit Ningyo-toge mine, 36 years after closure treatment: Impact of soil cover on woody plant establishment and dominance of the perennial herb Miscanthus sinensis.

Soil cover is a prevailing method used at mine sites to ensure the safety of hazardous materials and restore ecological functions when the base materials are unfavorable for plant growth. The former open-pit Ningyo-toge Mine was backfilled with overburden and neutralized smelting residues and covered with soil in 1987. After 36 years, the vegetation remained dominated by the perennial herb Miscanthus sinensis, and woody plant establishment did not progress successfully.

The first year results of mizoribine/tacrolimus-based multitarget treatment for consecutive patients with lupus nephritis.

Background: Despite the high efficacy of mycophenolate mofetil (MMF)/tacrolimus-based multitarget treatment, risks of infections are a matter of concern. In the present study, we clarified the potential of multitarget therapy using mizoribine opposed to MMF.

Methods: A total of 36 patients with biopsy-proven lupus nephritis were treated with mizoribine, tacrolimus, and glucocorticoids and then retrospectively evaluated.

SU-E-T-395: Achievability and Optimization of Synchrotron-Based Respiratory Gated Spot Scanning Proton Beam Delivery.

Purpose: The purpose was to investigate the interplay of residual motion in realistically delivered respiratory gated spot scanning proton beam by a synchrotron.

Methods: A MatriXX 2D ion-chamber array detector was placed on a moving platform. The platform with the 2D ion-chamber array detector was moved based on sin4 motion with 3s and 5s cycle and 20 mm amplitude.