Successful Treatment with Sirolimus of a Patient with a Novel CARD11 Germline Mutation in B-Cell Expansion with Nuclear Factor Kappa B and T-Cell Anergy: Case Report and Literature Review.

Purpose: B-cell expansion with nuclear factor kappa B and T-cell anergy (BENTA) is an inborn error of immunity characterized by congenital polyclonal B-cell lymphocyte expansion. In this report, we present a case of a girl diagnosed with BENTA carrying a novel CARD11 germline mutation, aiming to clarify the clinical presentation of BENTA by conducting a literature review.

Methods: Genetic analysis, including whole-exome sequencing, was performed using genomic DNA extracted from the patient's peripheral blood, oral mucosa, and fingernails.

Negative frequency-dependent selection through variations in seedling fitness due to genetic differentiation of parents' pair in a tropical rainforest tree, (Dipterocarpaceae).

Introduction: The role of syngameons in adaption to microgeographical environmental heterogeneity is important and could be one of the sources of rich species diversity in tropical forests. In addition, negative frequency- or density-dependent selection is one of the major processes contributing to the maintenance of genetic diversity.

Methods: To assess genetic factors that affect the fitness of seedlings of , a dominant canopy tree species in hill dipterocarp forests, the inter- and intra-population genetic structure of individuals from natural populations and individuals at two permanent plots in a hill dipterocarp forest with reproductive stage was studied.

Climate-Associated Genetic Variation and Projected Genetic Offsets for D. Don Under Future Climate Scenarios.

Revealing the spatial distribution of adaptive genetic variation is both a challenging and crucial task in evolutionary ecology, essential for understanding local adaptation within species, and in management, for predicting species responses to future climate change. This understanding is particularly important for long-lived tree species, which may not be able to migrate quickly enough to adapt to rapid climate changes and may need to rely on their standing genetic variation. In this study, we focused on , a major component of Japan's temperate forests and an important forestry species adapted to the humid environment of monsoon Asia.

Evolutionary Histories of and .

The genus is widely distributed, primarily in East Asia. is located at the northern limit of this genus distribution, and understanding changes in its distribution is crucial for understanding the evolution of plants in this region, as well as their relationship with geological history and climate change. Moreover, the classification of sect.