Publications by authors named "Y Tsujimura"
Article Synopsis
- Mycobacterium marinum is a leading cause of non-tuberculous mycobacterial infections, notably fish tank granuloma, and is more resistant to treatments compared to other NTM bacteria.
- Current treatment protocols for M. marinum are not well-established, and few studies have investigated how effective existing antibiotics are in living mammals.
- The study introduced a noninvasive imaging method to track M. marinum infections in mice, revealing that a combination of specific antibiotics helped clear the infection, while also highlighting the role of immune responses in granuloma development similar to tuberculosis.
FRET-based sensors are utilized for real-time measurements of cellular tension. However, transfection of the sensor gene shows low efficacy and is only effective for a short period. Reporter mice expressing such sensors have been developed, but sensor fluorescence has not been measured successfully using conventional confocal microscopy.
View Article and Find Full Text PDFEffects of Pedometer-Based Step-Feedback on Physical Activity of Severe COPD Patients.
Int J Chron Obstruct Pulmon Dis
November 2023
Article Synopsis
- - The study aimed to determine if adding step-feedback (step-FB) from pedometers to pulmonary rehabilitation (PR) programs could enhance physical activity in low-activity patients with severe chronic obstructive pulmonary disease (COPD).
- - A total of 31 patients (14 in the step-FB group and 17 in the control group) completed the PR program, showing significant improvements in dyspnea and exercise tolerance during the first rehabilitation session, while those with step-FB showed added benefits in daily steps and energy expenditure during the second session.
- - The findings suggest that integrating pedometer-based step-FB into PR programs effectively boosts physical activity levels in severe COPD patients by providing clear activity goals, supporting ongoing improvement in their overall physical
Non-tuberculosis mycobacterial (NTM) diseases are steadily increasing in prevalence and mortality worldwide. Mycobacterium avium and M. intracellulare, the two major pathogens of NTM diseases, are resistant to antibiotics, and chlorine, necessitating their capacity to survive in natural environments (e.
View Article and Find Full Text PDFAims: Dupuytren's contracture is characterized by increased fibrosis of the palmar aponeurosis, with eventual replacement of the surrounding fatty tissue with palmar fascial fibromatosis. We hypothesized that adipocytokines produced by adipose tissue in contact with the palmar aponeurosis might promote fibrosis of the palmar aponeurosis.
Methods: We compared the expression of the adipocytokines adiponectin and leptin in the adipose tissue surrounding the palmar aponeurosis of male patients with Dupuytren's contracture, and of male patients with carpal tunnel syndrome (CTS) as the control group.