Publications by authors named "Y Touil"
Polysomnography (PSG) is the gold standard for diagnosing obstructive sleep apnea (OSA) in children but not always available. Abbreviated exams exist, such as respiratory polygraphy (RP), but are less accurate for OSA diagnosis. Video recording (video-RP) may provide a more precise estimation of the total sleep time (TST) compared to RP alone.
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- Tumor dormancy is when cancer cells can hide and become resistant to treatments, making it hard to fully get rid of cancer.
- The study looked at how these dormant cancer cells work using special models of leukemia and melanoma, using lots of different scientific techniques to understand their behavior and find new ways to treat them.
- Researchers found unique gene mutations and changes in proteins in dormant cells, suggesting how they survive and resist therapies, which could help develop better treatments for patients.
Article Synopsis
- Multiple myeloma (MM) is an incurable blood cancer linked to MYC gene alterations, which currently lack effective drug-targeting options.
- Research identified glutaminase (GLS1) as a vital gene for the survival of MYC-overexpressing cells, while showing it is not a primary cancer driver.
- The study indicates that combining GLS1 and NAMPT inhibitors could be a promising approach to treat MYC-driven multiple myeloma by targeting cellular energy and synthesis pathways.
Acute myeloid leukemia (AML) is characterized by genetic aberrations in hematopoietic precursors of the myeloid lineage which lead to their defective maturation/function. While intensive chemotherapy protocols result in complete remission in 50 % to 80 % of AML patients, relapse occurs in the majority of cases. While calcium signalling is a well-known contributor to cancer hallmarks, few AML related studies have focused on relevant calcium targets.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) is a hematological malignancy with a high risk of relapse. This issue is associated with the development of mechanisms leading to drug resistance that are not yet fully understood. In this context, we previously showed the clinical significance of the ATP binding cassette subfamily B-member 1 (ABCB1) in AML patients, namely its association with stemness markers and an overall worth prognosis.
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