Publications by authors named "Y Totoki"

Article Synopsis
  • A study compared gene expression in the normal intestines of healthy individuals and colorectal cancer patients using a step biopsy procedure involving 78 participants.
  • Significant differences in gene expression were found not only between the healthy intestine regions but also in cancer patients' normal mucosa, indicating concealed alterations due to cancer.
  • These findings suggest that seemingly normal tissues in colorectal cancer patients might harbor cancer-predisposing conditions, highlighting potential pathways for new immunotherapy and treatments.
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Distal ulnar metaphyseal fractures are often treated conservatively with good clinical outcomes. Extensor carpi ulnaris (ECU) tendinopathy after conservative treatment for distal ulnar metaphyseal fractures has not been reported. We present a case of a 20-year-old university baseball player who developed ECU tendinopathy after conservative treatment for a distal ulnar metaphyseal fracture.

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The most problematic complication of external fixation is infection at the pin insertion site. Technology that improves the adhesion of the external fixation pin to the skin, subcutaneous tissue, and bone may prevent infection at the pin site. The purpose of this study is to formulate a calcium phosphate-fibroblast growth factor (Cp-FGF) coating on a stainless-steel external fixation pin and to verify its effectiveness in reducing infection at the pin site and its possible influence on bone fixation in animal experiments.

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In cases of distal radius fractures, the fixation of the volar lunate facet fragment is crucial for preventing volar subluxation of the carpal bones. This study aims to clarify the sex differences in the volar morphology of the lunate facet of the distal radius and its relationship with the transverse diameter of the distal radius. Sixty-four CT scans of healthy wrists (30 males and 34 females) were evaluated.

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Very well-differentiated adenocarcinoma of intestinal type is a distinct subtype of gastric cancer characterized by anastomosing glands with a hand-in-hand pattern and low-grade cytologic atypia resembling intestinal metaplasia. This is a slow-growing neoplasm with an indolent clinical course; however, a subset demonstrates transformation into adenocarcinoma with higher-grade histology, typically diffuse-type carcinoma, and behaves aggressively. This study aimed to better characterize the genomic and pathologic features, with a focus on factors associated with diffuse-type transformation.

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