Publications by authors named "Y Tomono"

Article Synopsis
  • The study focuses on Laminin 511 (LM511) and its fragment, 511E8, which is thought to enhance cell adhesion and behavior in human skin cells during culture.
  • Researchers examined the effects of 511E8 on reconstituted skin equivalents (SEs) formed from human foreskin keratinocytes and fibroblasts, comparing results from cultures with and without the 511E8 addition.
  • The findings showed that 511E8 improved the formation and continuity of basement membrane-like structures and increased the expression of key collagen genes, indicating its potential benefits in skin cell culture applications.
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Background: Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain 1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a leading cause of stroke, dementia and intracerebral haemorrhage (ICH). However, the molecular mechanisms of CSVD with ICH and COL4A1/COL4A2 variants remain obscure.

Methods: Vascular function and molecular investigations in mice with a Col4a1 missense mutation and heterozygous Col4a2 knock-out mice were combined with analysis of human brain endothelial cells harboring COL4A1/COL4A2 mutations, and brain tissue of patients with sporadic CSVD with ICH.

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Article Synopsis
  • Epidural and subdural hematomas often occur due to traumatic brain injuries, and while surgery is the main treatment, it's important to prevent complications like post-traumatic epilepsy.* -
  • In a study with rats, researchers found that a monoclonal antibody targeting high mobility group box-1 (HMGB1) effectively reduced inflammation and the release of inflammatory markers after a hematoma occurred.* -
  • The study suggests that using anti-HMGB1 therapy could help minimize brain inflammation and protect neural tissue, making it a potential addition to treatment protocols for epidural hematomas.*
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Article Synopsis
  • * A recent study explored the implications of a specific mutation (c.1771G>A, p.Gly591Ser) in COL4A6, which is associated with hearing loss and cochlear malformation, by examining Col4a6 knockout (KO) mice.
  • * Results revealed that Col4a6 KO mice had normal hearing thresholds and cochlear structures, suggesting that the harmful effects seen in humans with the COL4A6 mutation are likely due to the
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